Chlorine in PDB 7ucc: Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form

The structure of Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form, PDB code: 7ucc was solved by A.Kumar, M.C.Machius, G.Rudenko, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.23 / 1.94
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	47.939, 70.244, 122.17, 90, 90, 90
R / Rfree (%)	20.5 / 26.7

The structure of Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Chlorine atom in the Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form (pdb code 7ucc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form, PDB code: 7ucc:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl301 b:44.6 occ:1.00 HE F:ARG176 2.3 44.4 1.0 HH21 F:ARG176 2.8 35.1 1.0 HG3 F:ARG173 2.9 15.8 0.5 O F:HOH457 3.0 23.6 0.5 NE F:ARG176 3.2 36.5 1.0 HA F:ARG173 3.3 13.8 0.5 HA F:ARG173 3.3 13.8 0.5 HG3 F:ARG173 3.4 16.2 0.5 NH2 F:ARG176 3.5 28.8 1.0 HB2 F:ARG173 3.6 19.9 0.5 HG3 F:ARG176 3.6 22.5 1.0 HB3 F:ARG176 3.6 14.5 1.0 CG F:ARG173 3.7 12.7 0.5 HB2 F:ARG173 3.7 19.8 0.5 CZ F:ARG176 3.8 43.2 1.0 HD3 F:ARG173 3.9 17.2 0.5 HD3 F:ARG173 3.9 18.4 0.5 CB F:ARG173 3.9 16.1 0.5 CA F:ARG173 4.1 11.6 0.5 CG F:ARG173 4.1 13.0 0.5 CA F:ARG173 4.1 11.7 0.5 CG F:ARG176 4.1 18.3 1.0 CB F:ARG173 4.2 16.1 0.5 CB F:ARG176 4.2 11.6 1.0 CD F:ARG176 4.2 36.8 1.0 HB2 F:ARG176 4.2 14.5 1.0 CD F:ARG173 4.3 14.9 0.5 HH22 J:ARG292 4.3 66.4 1.0 HH22 F:ARG176 4.3 35.1 1.0 HD2 F:ARG173 4.4 18.4 0.5 HG2 F:ARG173 4.5 15.8 0.5 CD F:ARG173 4.6 13.9 0.5 HD3 F:ARG176 4.6 44.7 1.0 O F:HOH463 4.7 41.8 1.0 O F:ARG173 4.7 11.4 0.5 O F:ARG173 4.7 11.3 0.5 O F:HOH405 4.8 24.1 1.0 HB3 F:ARG173 4.9 19.9 0.5 HG3 F:ARG177 4.9 13.7 1.0 HD2 F:ARG176 4.9 44.7 1.0 O F:HOH457 4.9 28.2 0.5 HG2 F:ARG173 4.9 16.2 0.5 C F:ARG173 4.9 11.5 0.5 C F:ARG173 4.9 11.5 0.5

Chlorine binding site 2 out of 3 in the Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl302 b:39.0 occ:0.50 HE F:ARG177 2.7 14.8 1.0 O F:HOH432 2.8 41.2 1.0 HH22 F:ARG176 2.8 35.1 1.0 HH21 F:ARG177 2.9 15.8 1.0 NE F:ARG177 3.5 11.9 1.0 HH12 F:ARG176 3.6 22.8 1.0 NH2 F:ARG177 3.6 12.7 1.0 NH2 F:ARG176 3.7 28.8 1.0 HG2 F:ARG177 3.7 13.7 1.0 O F:HOH457 3.8 28.2 0.5 CZ F:ARG177 4.0 11.9 1.0 HH21 F:ARG176 4.2 35.1 1.0 NH1 F:ARG176 4.3 18.5 1.0 HH22 F:ARG177 4.3 15.8 1.0 CZ F:ARG176 4.5 43.2 1.0 CD F:ARG177 4.5 11.9 1.0 CG F:ARG177 4.5 11.2 1.0 HD3 F:ARG177 4.7 14.8 1.0 HG3 F:ARG177 4.9 13.7 1.0

Chlorine binding site 3 out of 3 in the Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Transcription Factor Fosb/Jund Bzip Domain in the Reduced Form within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl303 b:72.2 occ:1.00 HG2 F:GLU207 3.2 19.3 1.0 HD23 F:LEU204 3.4 17.1 1.0 HB2 F:GLU207 3.7 12.7 1.0 HB3 F:GLU207 3.9 12.7 1.0 CG F:GLU207 4.0 15.6 1.0 HA F:LEU204 4.0 18.6 1.0 O F:HOH470 4.1 49.5 1.0 CB F:GLU207 4.1 12.9 1.0 HD21 F:LEU204 4.2 17.1 1.0 CD2 F:LEU204 4.2 13.7 1.0 HG11 J:VAL321 4.3 13.9 1.0 HZ2 J:LYS325 4.3 74.8 1.0 HG F:LEU204 4.7 18.9 1.0 HG3 F:GLU207 4.7 19.3 1.0 HB3 F:GLU203 4.8 26.5 1.0 CD F:GLU207 4.8 38.6 1.0 HD22 F:LEU204 4.8 17.1 1.0 HZ3 J:LYS325 4.8 74.8 1.0 O F:GLU203 4.8 13.7 1.0 O F:HOH423 4.9 22.0 1.0 CA F:LEU204 4.9 15.0 1.0

A.Kumar, G.Aglyamova, Y.Y.Yim, A.O.Bailey, H.M.Lynch, R.T.Powell, N.D.Nguyen, Z.Rosenthal, W.N.Zhao, Y.Li, J.Chen, S.Fan, H.Lee, W.K.Russell, C.Stephan, A.J.Robison, S.J.Haggarty, E.J.Nestler, J.Zhou, M.Machius, G.Rudenko. Chemically Targeting the Redox Switch in AP1 Transcription Factor Delta Fosb. Nucleic Acids Res. V. 50 9548 2022.
ISSN: ESSN 1362-4962
PubMed: 36039764
DOI: 10.1093/NAR/GKAC710