Chlorine in PDB 7uge: Bromodomain of Cbp Liganded with Bms-536924

All present enzymatic activity of Bromodomain of Cbp Liganded with Bms-536924:
2.3.1.48;

The structure of Bromodomain of Cbp Liganded with Bms-536924, PDB code: 7uge was solved by E.Schonbrunn, M.Bikowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.83 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	43.122, 59.293, 57.147, 90, 109.81, 90
R / Rfree (%)	16.4 / 19.7

The binding sites of Chlorine atom in the Bromodomain of Cbp Liganded with Bms-536924 (pdb code 7uge). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Bromodomain of Cbp Liganded with Bms-536924, PDB code: 7uge:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Bromodomain of Cbp Liganded with Bms-536924


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Bromodomain of Cbp Liganded with Bms-536924 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1201 b:19.1 occ:1.00 CL16 A:N6I1201 0.0 19.1 1.0 C15 A:N6I1201 1.7 17.0 1.0 C17 A:N6I1201 2.7 12.4 1.0 C14 A:N6I1201 2.7 12.9 1.0 CG A:MET1193 3.7 15.8 1.0 CH2 A:TRP1151 3.7 13.6 1.0 O A:HOH1388 3.8 29.9 1.0 CB A:MET1193 3.8 12.2 1.0 CA A:ASP1190 3.9 13.1 1.0 CZ3 A:TRP1151 4.0 11.8 1.0 C13 A:N6I1201 4.0 14.4 1.0 C11 A:N6I1201 4.0 11.6 1.0 O A:HOH1307 4.1 13.5 1.0 CE B:LYS1139 4.1 16.1 1.0 O A:ILE1189 4.3 12.8 1.0 N A:ASP1190 4.4 14.2 1.0 CG2 A:ILE1189 4.4 15.5 1.0 C12 A:N6I1201 4.5 11.6 1.0 C A:ILE1189 4.5 16.7 1.0 CB A:ASP1190 4.5 13.9 1.0 O A:ASP1190 4.6 18.1 1.0 CG A:ASP1190 4.8 23.9 1.0 CG1 A:ILE1189 4.8 11.9 1.0 C A:ASP1190 4.8 17.4 1.0 CZ2 A:TRP1151 4.9 12.0 1.0 OD1 A:ASP1190 4.9 22.6 1.0 NZ B:LYS1139 5.0 13.8 1.0

Chlorine binding site 2 out of 2 in the Bromodomain of Cbp Liganded with Bms-536924


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Bromodomain of Cbp Liganded with Bms-536924 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1201 b:21.8 occ:1.00 CL16 B:N6I1201 0.0 21.8 1.0 C15 B:N6I1201 1.7 15.2 1.0 C17 B:N6I1201 2.7 14.9 1.0 C14 B:N6I1201 2.7 15.7 1.0 CH2 B:TRP1151 3.8 20.6 1.0 CG B:MET1193 3.8 23.3 1.0 O B:HOH1336 3.9 20.4 1.0 CB B:MET1193 3.9 20.7 1.0 C11 B:N6I1201 4.0 19.3 1.0 C13 B:N6I1201 4.0 15.9 1.0 CZ3 B:TRP1151 4.0 15.1 1.0 CA B:ASP1190 4.1 20.8 1.0 O B:HOH1365 4.2 40.5 1.0 CG2 B:ILE1189 4.3 13.8 1.0 O B:ILE1189 4.4 14.9 1.0 C12 B:N6I1201 4.5 15.6 1.0 N B:ASP1190 4.5 19.0 1.0 C B:ILE1189 4.6 19.8 1.0 CB B:ASP1190 4.7 20.0 1.0 OD1 B:ASP1190 4.8 31.5 1.0 O B:ASP1190 4.8 15.3 1.0 CZ2 B:TRP1151 4.8 20.0 1.0 CG1 B:ILE1189 4.8 14.8 1.0 CG B:ASP1190 4.8 26.8 1.0 C B:ASP1190 5.0 20.1 1.0

E.Schonbrunn, M.Bikowitz. Structural Basis of Cbp and EP300 Interaction with Kinase Inhibitors To Be Published.