Chlorine in PDB 7uos: Structure of WNK1 Inhibitor Complex

All present enzymatic activity of Structure of WNK1 Inhibitor Complex:
2.7.11.1;

The structure of Structure of WNK1 Inhibitor Complex, PDB code: 7uos was solved by R.Akella, E.J.Goldsmith, R.Akella, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.85 / 2.90
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	37.82, 57.532, 65.631, 90, 90.58, 90
R / Rfree (%)	22.2 / 29.5

The structure of Structure of WNK1 Inhibitor Complex also contains other interesting chemical elements:

Bromine

(Br)

1 atom

The binding sites of Chlorine atom in the Structure of WNK1 Inhibitor Complex (pdb code 7uos). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of WNK1 Inhibitor Complex, PDB code: 7uos:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of WNK1 Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of WNK1 Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:166.7 occ:1.00 CL1 A:WIB501 0.0 166.7 1.0 C13 A:WIB501 1.8 185.7 1.0 O A:HOH653 2.6 37.8 1.0 CL2 A:WIB501 2.9 193.0 1.0 O1 A:WIB501 2.9 209.7 1.0 S1 A:WIB501 2.9 187.6 1.0 BR1 A:WIB501 3.1 169.7 1.0 O4 A:WIB501 3.8 188.1 1.0 CA A:GLY228 3.8 65.0 1.0 O A:ILE227 4.1 76.0 1.0 C1 A:WIB501 4.3 130.8 1.0 N A:ARG229 4.4 76.4 1.0 O A:HOH644 4.5 15.8 1.0 C A:GLY228 4.7 66.8 1.0 C2 A:WIB501 4.7 106.8 1.0 O A:ARG229 4.8 72.8 1.0 O A:HOH632 4.8 8.3 1.0 N A:GLY228 4.8 66.9 1.0 C A:ILE227 4.8 73.5 1.0

Chlorine binding site 2 out of 2 in the Structure of WNK1 Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of WNK1 Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:193.0 occ:1.00 CL2 A:WIB501 0.0 193.0 1.0 C13 A:WIB501 1.8 185.7 1.0 O A:HOH632 2.3 8.3 1.0 C2 A:WIB501 2.6 106.8 1.0 CL1 A:WIB501 2.9 166.7 1.0 S1 A:WIB501 2.9 187.6 1.0 C1 A:WIB501 2.9 130.8 1.0 BR1 A:WIB501 3.1 169.7 1.0 C3 A:WIB501 3.6 96.5 1.0 O1 A:WIB501 3.6 209.7 1.0 O2 A:WIB501 3.7 71.4 1.0 CA A:GLY228 3.8 65.0 1.0 N A:ARG229 3.9 76.4 1.0 O4 A:WIB501 4.0 188.1 1.0 N1 A:WIB501 4.1 93.0 1.0 C12 A:WIB501 4.1 100.6 1.0 O A:ARG229 4.2 72.8 1.0 C A:GLY228 4.3 66.8 1.0 C A:ARG229 4.6 88.8 1.0 C4 A:WIB501 4.6 94.6 1.0 C11 A:WIB501 4.8 91.3 1.0 CA A:ARG229 4.9 84.9 1.0 CE A:LYS233 5.0 61.1 1.0 O A:ILE227 5.0 76.0 1.0

R.Akella, E.J.Goldsmith. Structure of WNK1 Inhibitor Complex To Be Published.