Chlorine in PDB 7usz: Human Ddah-1, Holo (Zn-Bound) Form

All present enzymatic activity of Human Ddah-1, Holo (Zn-Bound) Form:
3.5.3.18;

The structure of Human Ddah-1, Holo (Zn-Bound) Form, PDB code: 7usz was solved by C.A.Smith, Y.T.Ghebre, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.55 / 1.65
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	44.968, 47.634, 146.965, 90, 94.61, 90
R / Rfree (%)	15.1 / 19.9

The structure of Human Ddah-1, Holo (Zn-Bound) Form also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Human Ddah-1, Holo (Zn-Bound) Form (pdb code 7usz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Ddah-1, Holo (Zn-Bound) Form, PDB code: 7usz:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Ddah-1, Holo (Zn-Bound) Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Ddah-1, Holo (Zn-Bound) Form within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl302 b:84.7 occ:1.00 O B:HOH415 3.4 43.2 1.0 CE1 B:HIS255 3.6 26.4 1.0 NE2 B:HIS232 4.0 27.6 1.0 CD2 B:HIS232 4.0 27.4 1.0 CD B:PRO183 4.1 24.6 1.0 CE1 B:HIS232 4.1 27.0 1.0 CG B:HIS232 4.1 26.1 1.0 ND1 B:HIS232 4.2 26.5 1.0 CG B:PRO183 4.2 27.1 1.0 NE2 B:HIS255 4.3 24.1 1.0 ND1 B:HIS255 4.3 25.9 1.0 CB B:HIS232 4.8 23.1 1.0 O B:HOH488 4.9 30.1 1.0 O B:HOH418 5.0 63.9 1.0

Chlorine binding site 2 out of 2 in the Human Ddah-1, Holo (Zn-Bound) Form


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Ddah-1, Holo (Zn-Bound) Form within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl303 b:76.7 occ:1.00 NE2 B:GLN46 3.3 26.6 1.0 CG B:GLN46 3.7 22.4 1.0 CD B:ARG42 4.0 36.3 1.0 CD B:GLN46 4.0 24.3 1.0 OG B:SER261 4.3 36.7 1.0 CB B:SER261 4.3 29.4 1.0 CG B:ARG42 4.7 28.2 1.0 NE B:ARG42 4.9 39.3 1.0 NH1 B:ARG42 4.9 42.2 1.0

C.A.Smith, A.Ebrahimpour, L.Novikova, D.Farina, A.O.Bailey, W.K.Russell, A.Jain, A.B.Saltzman, A.Malovannaya, B.V.V.Prasad, L.Hu, Y.T.Ghebre. Esomeprazole Covalently Interacts with the Cardiovascular Enzyme Dimethylarginine Dimethylaminohydrolase: Insights Into the Cardiovascular Risk of Proton Pump Inhibitors. Biochim Biophys Acta Gen V.1866 30149 2022SUBJ.
ISSN: ISSN 1872-8006
PubMed: 35472493
DOI: 10.1016/J.BBAGEN.2022.130149