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Chlorine in PDB 7uyf: Human PRMT5:MEP50 Structure with Fragment 4 and Mta BoundEnzymatic activity of Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound
All present enzymatic activity of Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound:
2.1.1.320; Protein crystallography data
The structure of Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound, PDB code: 7uyf
was solved by
R.J.Gunn,
J.D.Lawson,
C.R.Smith,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound
(pdb code 7uyf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound, PDB code: 7uyf: Jump to Chlorine binding site number: 1; 2; 3; Chlorine binding site 1 out of 3 in 7uyfGo back to Chlorine Binding Sites List in 7uyf
Chlorine binding site 1 out
of 3 in the Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound
Mono view Stereo pair view
Chlorine binding site 2 out of 3 in 7uyfGo back to Chlorine Binding Sites List in 7uyf
Chlorine binding site 2 out
of 3 in the Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound
Mono view Stereo pair view
Chlorine binding site 3 out of 3 in 7uyfGo back to Chlorine Binding Sites List in 7uyf
Chlorine binding site 3 out
of 3 in the Human PRMT5:MEP50 Structure with Fragment 4 and Mta Bound
Mono view Stereo pair view
Reference:
C.R.Smith,
S.Kulyk,
M.U.D.Ahmad,
V.Arkhipova,
J.G.Christensen,
R.J.Gunn,
A.Ivetac,
J.M.Ketcham,
J.Kuehler,
J.D.Lawson,
N.C.Thomas,
X.Wang,
M.A.Marx.
Fragment Optimization and Elaboration Strategies - the Discovery of Two Lead Series of PRMT5/Mta Inhibitors From Five Fragment Hits Rsc Med Chem 2022.
Page generated: Tue Apr 4 22:02:48 2023
ISSN: ESSN 2632-8682 DOI: 10.1039/D2MD00163B |
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