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Chlorine in PDB 7v0z: Factor Xia in Complex with Compound 2AEnzymatic activity of Factor Xia in Complex with Compound 2A
All present enzymatic activity of Factor Xia in Complex with Compound 2A:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2A, PDB code: 7v0z
was solved by
P.L.Shaffer,
J.Spurlino,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with Compound 2A
(pdb code 7v0z). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with Compound 2A, PDB code: 7v0z: Chlorine binding site 1 out of 1 in 7v0zGo back to Chlorine Binding Sites List in 7v0z
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2A
Mono view Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Tue Apr 4 22:02:52 2023
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
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