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Chlorine in PDB 7v11: Factor Xia in Complex with Compound 2EEnzymatic activity of Factor Xia in Complex with Compound 2E
All present enzymatic activity of Factor Xia in Complex with Compound 2E:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2E, PDB code: 7v11
was solved by
P.L.Shaffer,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7v11:
The structure of Factor Xia in Complex with Compound 2E also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with Compound 2E
(pdb code 7v11). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with Compound 2E, PDB code: 7v11: Chlorine binding site 1 out of 1 in 7v11Go back to Chlorine Binding Sites List in 7v11
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2E
Mono view Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Tue Jul 30 05:15:48 2024
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
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