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Chlorine in PDB 7v12: Factor Xia in Complex with Compound 2FEnzymatic activity of Factor Xia in Complex with Compound 2F
All present enzymatic activity of Factor Xia in Complex with Compound 2F:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2F, PDB code: 7v12
was solved by
P.L.Shaffer,
J.Spurlino,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7v12:
The structure of Factor Xia in Complex with Compound 2F also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with Compound 2F
(pdb code 7v12). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with Compound 2F, PDB code: 7v12: Chlorine binding site 1 out of 1 in 7v12Go back to Chlorine Binding Sites List in 7v12
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2F
Mono view Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Tue Apr 4 22:02:52 2023
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
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