|
Chlorine in PDB 7v16: Factor Xia in Complex with Compound 2JEnzymatic activity of Factor Xia in Complex with Compound 2J
All present enzymatic activity of Factor Xia in Complex with Compound 2J:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2J, PDB code: 7v16
was solved by
P.L.Shaffer,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7v16:
The structure of Factor Xia in Complex with Compound 2J also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with Compound 2J
(pdb code 7v16). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with Compound 2J, PDB code: 7v16: Chlorine binding site 1 out of 1 in 7v16Go back to Chlorine Binding Sites List in 7v16
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2J
Mono view Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Tue Jul 30 05:17:34 2024
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
Last articlesZn in 9JYWZn in 9IR4 Zn in 9IR3 Zn in 9GMX Zn in 9GMW Zn in 9JEJ Zn in 9ERF Zn in 9ERE Zn in 9EGV Zn in 9EGW |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |