Chlorine in PDB 7wal: Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co

All present enzymatic activity of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co:
6.1.1.17;

The structure of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co, PDB code: 7wal was solved by V.Sharma, Y.Manickam, P.Babbar, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.10 / 2.29
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	158.73, 46.11, 95.35, 90, 110.73, 90
R / Rfree (%)	20.9 / 25.6

The structure of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co also contains other interesting chemical elements:

Cobalt

(Co)

8 atoms

The binding sites of Chlorine atom in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co (pdb code 7wal). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co, PDB code: 7wal:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1009 b:116.4 occ:1.00 CB A:SER548 3.2 92.1 1.0 N A:SER548 3.3 100.0 1.0 N A:MET547 3.8 101.8 1.0 CA A:SER548 3.9 95.6 1.0 CG1 A:VAL546 4.2 99.3 1.0 CA A:VAL546 4.3 86.7 1.0 C A:MET547 4.4 98.5 1.0 OG A:SER548 4.4 93.1 1.0 C A:VAL546 4.6 93.7 1.0 CA A:MET547 4.7 98.9 1.0 CB A:VAL546 4.7 86.5 1.0

Chlorine binding site 2 out of 3 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1010 b:94.0 occ:1.00 OG A:SER538 2.9 85.9 1.0 N A:SER538 3.4 65.0 1.0 NZ A:LYS329 3.7 62.0 1.0 CB A:SER538 4.0 74.3 1.0 CA A:PHE537 4.0 67.2 1.0 CB A:PHE537 4.1 51.3 1.0 C A:PHE537 4.2 66.0 1.0 CA A:SER538 4.3 70.2 1.0 CE A:LYS329 4.4 53.9 1.0 O A:SER538 4.8 65.6 1.0

Chlorine binding site 3 out of 3 in the Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Glutamyl-Trna Synthetase From Plasmodium Falciparum (Pfers) in Complex with Co within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1011 b:91.3 occ:1.00 NH2 A:ARG577 3.4 80.0 1.0 NH1 A:ARG577 3.6 75.5 1.0 CZ A:ARG577 3.9 72.6 1.0 OD2 A:ASP566 4.8 66.2 1.0 OG A:SER563 4.9 89.7 1.0

V.K.Sharma, J.Chhibber-Goel, M.Yogavel, A.Sharma. Structural Characterization of Glutamyl-Trna Synthetase (Glurs) From Plasmodium Falciparum. Mol.Biochem.Parasitol. V. 253 11530 2022.
ISSN: ISSN 0166-6851
PubMed: 36370911
DOI: 10.1016/J.MOLBIOPARA.2022.111530