Chlorine in PDB 7wgo: X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization

Enzymatic activity of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization

All present enzymatic activity of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization:
2.3.1.48;

Protein crystallography data

The structure of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization, PDB code: 7wgo was solved by S.Kamata, A.Honda, M.Akahane, Y.Machida, K.Uchii, Y.Shiiyama, R.Masuda, T.Oyama, I.Ishii, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.45 / 2.36
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 49.659, 64.946, 124.32, 90, 90, 90
R / Rfree (%) 19.5 / 22.5

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization (pdb code 7wgo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization, PDB code: 7wgo:

Chlorine binding site 1 out of 1 in 7wgo

Go back to Chlorine Binding Sites List in 7wgo
Chlorine binding site 1 out of 1 in the X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Human Ppar Gamma Ligand Binding Domain-Bezafibrate Co-Rystals Obtained By Co-Crystallization within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:93.2
occ:1.00
 CL A:PEM501 0.0 93.2 1.0
C4 A:PEM501 1.8 70.1 1.0
C5 A:PEM501 2.7 78.9 1.0
C3 A:PEM501 2.7 73.6 1.0
H51 A:PEM501 2.8 94.6 1.0
H31 A:PEM501 2.8 88.3 1.0
NH2 A:ARG288 3.3 65.9 1.0
C6 A:PEM501 4.0 79.9 1.0
C2 A:PEM501 4.0 67.7 1.0
NE A:ARG288 4.2 56.7 1.0
CZ A:ARG288 4.2 52.3 1.0
C1 A:PEM501 4.6 80.4 1.0
CB A:MET329 4.6 38.1 1.0
OE1 A:GLU295 4.6 53.9 1.0
HC6 A:PEM501 4.8 95.9 1.0
CB A:ALA292 4.8 37.2 1.0
H21 A:PEM501 4.8 81.2 1.0

Reference:

A.Honda, S.Kamata, M.Akahane, Y.Machida, K.Uchii, Y.Shiiyama, Y.Habu, S.Miyawaki, C.Kaneko, T.Oyama, I.Ishii. Functional and Structural Insights Into Human Ppar Alpha / Delta / Gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. Int J Mol Sci V. 23 2022.
ISSN: ESSN 1422-0067
PubMed: 35563117
DOI: 10.3390/IJMS23094726
Page generated: Tue Jul 30 05:38:32 2024

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