Chlorine in PDB 7wn7: Crystal Structure of Hearnpv P26

The structure of Crystal Structure of Hearnpv P26, PDB code: 7wn7 was solved by W.Kuang, Z.Hu, P.Gong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.74 / 1.90
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	194.749, 69.236, 52.746, 90, 102.18, 90
R / Rfree (%)	18.4 / 21.1

The binding sites of Chlorine atom in the Crystal Structure of Hearnpv P26 (pdb code 7wn7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Hearnpv P26, PDB code: 7wn7:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of Hearnpv P26


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Hearnpv P26 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:30.7 occ:1.00 O B:HOH528 3.0 27.1 1.0 O A:HOH488 3.0 23.7 1.0 OG A:SER175 3.1 23.8 1.0 N A:GLY176 3.6 23.0 1.0 CA A:GLY176 3.6 22.7 1.0 CD B:ARG257 3.7 22.9 1.0 CD B:ARG259 3.7 24.5 1.0 C A:SER175 3.8 20.8 1.0 CB A:SER175 3.8 19.4 1.0 C A:GLY176 3.9 20.1 1.0 CG B:ARG257 3.9 22.2 1.0 CG B:ARG259 4.0 24.8 1.0 O A:SER175 4.0 20.2 1.0 CG A:GLN177 4.1 24.7 1.0 O A:GLY176 4.2 20.7 1.0 NE2 A:GLN177 4.2 31.2 1.0 O A:HOH545 4.3 44.3 1.0 N A:GLN177 4.4 21.7 1.0 O A:HOH515 4.5 32.6 1.0 CA A:SER175 4.5 18.4 1.0 CD A:GLN177 4.6 32.2 1.0 CB B:ARG259 4.6 19.5 1.0 O A:HOH458 4.7 36.6 1.0 O A:HOH541 4.9 29.3 1.0 N B:ARG259 5.0 19.0 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of Hearnpv P26


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Hearnpv P26 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl302 b:41.7 occ:1.00 O B:HOH540 2.6 36.6 1.0 O B:LEU145 2.8 23.1 1.0 ND2 B:ASN25 2.9 28.0 1.0 N B:LEU145 3.4 23.1 1.0 CB B:LEU145 3.7 23.7 1.0 C B:LEU145 3.7 25.5 1.0 O B:HOH459 3.7 34.4 1.0 CA B:LEU145 3.8 25.7 1.0 CG B:ASN25 3.9 27.9 1.0 CB B:LYS144 4.0 29.0 1.0 OD1 B:ASN25 4.1 23.9 1.0 C B:LYS144 4.1 25.5 1.0 CG1 B:VAL42 4.1 27.0 1.0 OD2 B:ASP43 4.2 37.2 1.0 O B:HOH439 4.3 32.5 1.0 CA B:LYS144 4.4 29.2 1.0 CG B:LEU145 4.7 24.4 1.0 OD1 B:ASP43 4.8 35.7 1.0 CG B:ASP43 4.8 34.1 1.0 CD2 B:LEU145 4.8 24.8 1.0 O B:LYS144 4.9 25.0 1.0 N B:VAL146 4.9 23.3 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of Hearnpv P26


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Hearnpv P26 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl303 b:29.6 occ:1.00 O B:HOH507 2.9 25.0 1.0 O A:HOH524 3.0 24.8 1.0 OG B:SER175 3.0 20.0 1.0 CA B:GLY176 3.6 21.1 1.0 N B:GLY176 3.6 20.7 1.0 CD A:ARG259 3.6 23.4 1.0 CD A:ARG257 3.7 25.4 1.0 C B:SER175 3.8 21.0 1.0 CB B:SER175 3.8 18.0 1.0 CG A:ARG259 3.9 23.7 1.0 C B:GLY176 3.9 20.4 1.0 O B:SER175 4.0 20.9 1.0 CG A:ARG257 4.0 22.3 1.0 NE2 B:GLN177 4.1 30.0 1.0 CG B:GLN177 4.1 26.0 1.0 O B:GLY176 4.2 17.9 1.0 O B:HOH519 4.3 30.0 1.0 O B:HOH549 4.4 39.5 1.0 N B:GLN177 4.5 21.6 1.0 CA B:SER175 4.5 20.1 1.0 CD B:GLN177 4.6 31.7 1.0 CB A:ARG259 4.6 20.8 1.0 O B:HOH474 4.6 36.3 1.0 O B:HOH543 4.7 27.0 1.0 N A:ARG259 5.0 19.1 1.0

M.Yin, W.Kuang, Q.Wang, X.Wang, C.Yuan, Z.Lin, H.Zhang, F.Deng, H.Jiang, P.Gong, Z.Zou, Z.Hu, M.Wang. Dual Roles and Evolutionary Implications of P26/Poxin in Antagonizing Intracellular Cgas-Sting and Extracellular Melanization Immunity. Nat Commun 2022.
ISSN: ESSN 2041-1723