Chlorine in PDB 7wok: Crystal Structure of Hsa Soaked with Cisplatin For One Week

Protein crystallography data

The structure of Crystal Structure of Hsa Soaked with Cisplatin For One Week, PDB code: 7wok was solved by S.L.Chen, C.Yuan, L.G.Jiang, Z.P.Luo, M.D.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.55 / 2.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 58.376, 180.518, 58.503, 90, 103.87, 90
R / Rfree (%) 20.7 / 24.4

Other elements in 7wok:

The structure of Crystal Structure of Hsa Soaked with Cisplatin For One Week also contains other interesting chemical elements:

Platinum (Pt) 10 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Hsa Soaked with Cisplatin For One Week (pdb code 7wok). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Hsa Soaked with Cisplatin For One Week, PDB code: 7wok:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 7wok

Go back to Chlorine Binding Sites List in 7wok
Chlorine binding site 1 out of 2 in the Crystal Structure of Hsa Soaked with Cisplatin For One Week


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Hsa Soaked with Cisplatin For One Week within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl602

b:108.6
occ:0.56
CL1 A:CPT602 0.0 108.6 0.6
PT1 A:CPT602 2.3 139.1 0.6
N1 A:CPT602 3.1 88.6 0.6
SD A:MET329 3.1 108.4 1.0
CE A:MET329 3.5 177.0 1.0
OD1 A:ASP308 4.0 146.9 1.0
CB A:MET329 4.2 154.7 1.0
CZ A:PHE309 4.3 131.8 1.0
CG A:MET329 4.3 146.7 1.0
N2 A:CPT602 4.4 111.1 0.6
CE1 A:PHE309 4.5 101.9 1.0
CD1 A:PHE326 4.5 89.3 1.0
CE1 A:PHE326 4.6 110.5 1.0

Chlorine binding site 2 out of 2 in 7wok

Go back to Chlorine Binding Sites List in 7wok
Chlorine binding site 2 out of 2 in the Crystal Structure of Hsa Soaked with Cisplatin For One Week


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Hsa Soaked with Cisplatin For One Week within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl602

b:132.0
occ:0.67
CL1 B:CPT602 0.0 132.0 0.7
PT1 B:CPT602 2.3 139.5 0.7
N1 B:CPT602 3.0 120.5 0.7
SD B:MET329 3.3 107.4 1.0
CE B:MET329 4.0 136.3 1.0
N2 B:CPT602 4.4 92.4 0.7
CG B:MET329 4.6 146.4 1.0
CB B:MET329 4.6 113.1 1.0

Reference:

S.L.Chen, C.Yuan, L.G.Jiang, Z.P.Luo, M.D.Huang. Crystallographic Analysis of Interaction Between Cisplatin and Human Serum Albumin: Effect of Fatty Acid. Int.J.Biol.Macromol. V. 216 172 2022.
ISSN: ISSN 0141-8130
PubMed: 35788007
DOI: 10.1016/J.IJBIOMAC.2022.06.181
Page generated: Tue Apr 4 22:14:25 2023

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