Chlorine in PDB 7x2f: Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex

The binding sites of Chlorine atom in the Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex (pdb code 7x2f). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex, PDB code: 7x2f:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl502 b:85.1 occ:1.00 CL9 F:G4C502 0.0 85.1 1.0 C08 F:G4C502 1.8 85.1 1.0 C07 F:G4C502 2.7 85.1 1.0 C10 F:G4C502 2.8 85.1 1.0 C06 F:G4C502 3.0 85.1 1.0 C17 F:G4C502 3.7 85.1 1.0 CB F:TRP123 3.8 63.4 1.0 CG F:TRP123 3.8 63.4 1.0 CD2 F:TRP123 3.8 63.4 1.0 C05 F:G4C502 3.9 85.1 1.0 CE3 F:TRP123 3.9 63.4 1.0 C13 F:G4C502 4.0 85.1 1.0 C11 F:G4C502 4.0 85.1 1.0 CA F:TYR131 4.1 70.1 1.0 CB F:LYS134 4.3 78.5 1.0 C16 F:G4C502 4.3 85.1 1.0 N04 F:G4C502 4.5 85.1 1.0 CD1 F:TYR131 4.5 70.1 1.0 N F:TYR131 4.5 70.1 1.0 O15 F:G4C502 4.5 85.1 1.0 CD1 F:TRP123 4.5 63.4 1.0 C12 F:G4C502 4.6 85.1 1.0 CE2 F:TRP123 4.6 63.4 1.0 CB F:TYR131 4.7 70.1 1.0 CG F:ARG130 4.7 79.8 1.0 CZ3 F:TRP123 4.7 63.4 1.0 C F:ARG130 4.7 79.8 1.0 O F:ARG130 4.7 79.8 1.0 CB F:ARG130 4.8 79.8 1.0 CE F:MET135 4.8 73.8 1.0 O F:TRP123 4.9 63.4 1.0 CD F:LYS134 4.9 78.5 1.0 CA F:TRP123 4.9 63.4 1.0 O F:TYR131 4.9 70.1 1.0 N F:MET135 5.0 73.8 1.0 NE1 F:TRP123 5.0 63.4 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of the Dopamine and LY3154207-Bound D1 Dopamine Receptor and Mini-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl502 b:85.1 occ:1.00 CL4 F:G4C502 0.0 85.1 1.0 C13 F:G4C502 1.8 85.1 1.0 C12 F:G4C502 2.7 85.1 1.0 C07 F:G4C502 2.8 85.1 1.0 C19 F:CLR501 3.0 84.8 1.0 C06 F:G4C502 3.1 85.1 1.0 O15 F:G4C502 3.1 85.1 1.0 C05 F:G4C502 3.4 85.1 1.0 C2 F:CLR501 3.8 84.8 1.0 C4 F:CLR501 3.8 84.8 1.0 C11 F:G4C502 4.0 85.1 1.0 C08 F:G4C502 4.0 85.1 1.0 C10 F:CLR501 4.2 84.8 1.0 C3 F:CLR501 4.2 84.8 1.0 O1 F:CLR501 4.2 84.8 1.0 NH1 F:ARG130 4.4 79.8 1.0 C5 F:CLR501 4.4 84.8 1.0 NE1 F:TRP123 4.5 63.4 1.0 C1 F:CLR501 4.5 84.8 1.0 CZ2 F:TRP123 4.5 63.4 1.0 C10 F:G4C502 4.6 85.1 1.0 CE2 F:TRP123 4.6 63.4 1.0 N04 F:G4C502 4.8 85.1 1.0 O01 F:G4C502 4.9 85.1 1.0

X.Teng, S.Chen, Y.Nie, P.Xiao, X.Yu, Z.Shao, S.Zheng. Ligand Recognition and Biased Agonism of the D1 Dopamine Receptor. Nat Commun V. 13 3186 2022.
ISSN: ESSN 2041-1723
PubMed: 35676276
DOI: 10.1038/S41467-022-30929-W