Chlorine in PDB 7x97: Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex

The structure of Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex, PDB code: 7x97 was solved by S.H.Kao, R.B.Satange, M.H.Hou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.57 / 1.95
Space group	P 63 2 2
Cell size a, b, c (Å), α, β, γ (°)	43.452, 43.452, 139.365, 90, 90, 120
R / Rfree (%)	22.9 / 28.2

The structure of Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex also contains other interesting chemical elements:

Potassium	(K)	1 atom
Zinc	(Zn)	5 atoms

The binding sites of Chlorine atom in the Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex (pdb code 7x97). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex, PDB code: 7x97:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl105 b:55.7 occ:0.33 K A:K104 2.8 43.5 0.3 OP2 A:DA1 4.9 90.8 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Actinomycin D-Echinomycin-D(Agcccgt/Acgggct) Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl103 b:28.2 occ:1.00 ZN B:ZN102 2.2 16.6 1.0 O G:HOH201 3.1 13.8 1.0 N7 B:DG3 3.3 20.5 1.0 O6 B:DG3 3.5 18.3 1.0 O A:HOH214 3.8 19.6 1.0 C5 B:DG3 4.0 19.7 1.0 C6 B:DG3 4.1 20.6 1.0 N4 G:QUI101 4.4 11.5 1.0 C8 B:DG3 4.4 21.3 1.0 C5 G:QUI101 4.7 11.5 1.0 C10 G:QUI101 4.9 11.5 1.0

R.Satange, S.H.Kao, C.M.Chien, S.H.Chou, C.C.Lin, S.Neidle, M.H.Hou. Staggered Intercalation of Dna Duplexes with Base-Pair Modulation By Two Distinct Drug Molecules Induces Asymmetric Backbone Twisting and Structure Polymorphism. Nucleic Acids Res. V. 50 8867 2022.
ISSN: ESSN 1362-4962
PubMed: 35871296
DOI: 10.1093/NAR/GKAC629