Chlorine in PDB 7xhh: High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4

All present enzymatic activity of High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4:
3.4.19.12;

The structure of High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4, PDB code: 7xhh was solved by H.B.Sun, X.A.Wen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.45 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	76.034, 68.904, 81.788, 90, 100.32, 90
R / Rfree (%)	19.6 / 21.8

The binding sites of Chlorine atom in the High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4 (pdb code 7xhh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4, PDB code: 7xhh:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl601 b:70.5 occ:1.00 CL1 A:DYO601 0.0 70.5 1.0 C14 A:DYO601 1.8 62.9 1.0 H9 A:DYO601 2.7 71.0 1.0 C15 A:DYO601 2.8 67.4 1.0 C13 A:DYO601 2.9 61.1 1.0 H1 A:DYO601 2.9 81.0 1.0 H20 A:DYO601 3.1 69.4 1.0 C12 A:DYO601 3.3 59.1 1.0 CD A:LYS420 3.4 65.5 1.0 H21 A:DYO601 3.4 69.4 1.0 O A:ARG408 3.5 67.8 1.0 C33 A:DYO601 3.6 57.8 1.0 CE A:LYS420 3.6 62.1 1.0 CB A:ARG408 3.7 61.3 1.0 CG A:LYS420 3.7 67.3 1.0 C A:ARG408 3.8 65.8 1.0 N10 A:DYO601 4.0 56.0 1.0 H8 A:DYO601 4.0 71.0 1.0 CB A:LYS420 4.2 70.7 1.0 C16 A:DYO601 4.2 67.7 1.0 ND1 A:HIS456 4.2 60.9 1.0 C18 A:DYO601 4.3 64.1 1.0 N A:PHE409 4.3 66.6 1.0 CA A:ARG408 4.4 62.7 1.0 O06 A:DYO601 4.4 55.6 1.0 CB A:PHE409 4.5 72.2 1.0 H30 A:DYO601 4.6 67.3 1.0 NZ A:LYS420 4.6 57.2 1.0 CA A:LYS420 4.7 72.1 1.0 CE1 A:HIS456 4.7 62.6 1.0 CA A:PHE409 4.8 72.5 1.0 CG A:HIS456 4.8 60.6 1.0 C17 A:DYO601 4.8 67.0 1.0 C35 A:DYO601 4.9 56.0 1.0 CG A:ARG408 4.9 60.6 1.0 C32 A:DYO601 5.0 57.3 1.0

Chlorine binding site 2 out of 2 in the High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of High-Resolution X-Ray Cocrystal Structure of USP7 in Complex with X4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:63.0 occ:1.00 CL1 B:DYO601 0.0 63.0 1.0 C14 B:DYO601 1.8 58.5 1.0 H8 B:DYO601 2.7 64.8 1.0 H20 B:DYO601 2.8 58.8 1.0 C15 B:DYO601 2.8 60.8 1.0 C13 B:DYO601 2.9 51.3 1.0 H1 B:DYO601 2.9 73.0 1.0 C12 B:DYO601 3.2 53.9 1.0 H21 B:DYO601 3.3 58.8 1.0 O B:ARG408 3.3 59.4 1.0 C33 B:DYO601 3.4 48.9 1.0 CB B:ARG408 3.6 55.6 1.0 C B:ARG408 3.7 61.1 1.0 CG B:LYS420 3.8 62.6 1.0 CE B:LYS420 3.8 58.5 1.0 N10 B:DYO601 3.8 50.8 1.0 CD B:LYS420 3.9 61.0 1.0 H9 B:DYO601 4.0 64.8 1.0 O06 B:DYO601 4.2 49.9 1.0 N B:PHE409 4.2 59.8 1.0 C16 B:DYO601 4.2 61.1 1.0 C18 B:DYO601 4.3 56.1 1.0 CA B:ARG408 4.3 56.8 1.0 CB B:LYS420 4.3 62.8 1.0 ND1 B:HIS456 4.4 55.7 1.0 H30 B:DYO601 4.4 59.4 1.0 CB B:PHE409 4.5 61.8 1.0 H6 B:DYO601 4.7 52.2 1.0 CE1 B:HIS456 4.7 59.0 1.0 CA B:PHE409 4.7 64.4 1.0 C35 B:DYO601 4.7 49.4 1.0 CA B:LYS420 4.8 66.8 1.0 C32 B:DYO601 4.8 48.1 1.0 C17 B:DYO601 4.8 62.8 1.0 NZ B:LYS420 4.8 52.7 1.0 H19 B:DYO601 4.8 57.9 1.0 CG B:ARG408 4.8 53.5 1.0 CG B:HIS456 5.0 54.6 1.0 H10 B:DYO601 5.0 67.5 1.0

X.A.Wen, H.B.Sun, X.A.Wen. N/A N/A.