Chlorine in PDB 7xjf: Crystal Structure of 6MW3211 Fab in Complex with CD47

The structure of Crystal Structure of 6MW3211 Fab in Complex with CD47, PDB code: 7xjf was solved by J.Wang, R.Wang, S.Jiao, S.Wang, J.Zhang, M.Zhang, M.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.83 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	60.83, 100.48, 163.32, 90, 90, 90
R / Rfree (%)	18.7 / 23.1

The binding sites of Chlorine atom in the Crystal Structure of 6MW3211 Fab in Complex with CD47 (pdb code 7xjf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of 6MW3211 Fab in Complex with CD47, PDB code: 7xjf:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of 6MW3211 Fab in Complex with CD47


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of 6MW3211 Fab in Complex with CD47 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:45.3 occ:1.00 O B:HOH484 2.8 25.9 1.0 O A:HOH452 3.3 23.8 1.0 ND1 A:HIS175 3.3 26.5 1.0 CE1 A:HIS175 3.8 28.2 1.0 OE2 B:GLU165 4.0 33.0 1.0 O A:HOH418 4.0 28.4 1.0 CD B:GLU165 4.2 36.8 1.0 CB B:THR164 4.4 17.4 1.0 OD2 B:ASP167 4.5 31.9 1.0 CG A:HIS175 4.5 24.7 1.0 OE1 B:GLU165 4.6 33.5 1.0 O B:HOH445 4.6 34.8 1.0 CG2 B:THR164 4.6 17.0 1.0 O A:VAL174 4.6 26.8 1.0 O B:GLU165 4.7 21.4 1.0 CA A:HIS175 4.8 20.1 1.0 CG B:GLU165 4.9 19.1 1.0 OG1 B:THR164 4.9 18.1 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of 6MW3211 Fab in Complex with CD47


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of 6MW3211 Fab in Complex with CD47 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:48.4 occ:1.00 O B:HOH425 4.0 22.1 1.0 CG1 B:VAL163 4.2 15.0 1.0 O B:HOH500 4.3 17.3 1.0 O B:GLU161 4.9 21.0 1.0 CB B:VAL163 4.9 10.8 1.0 OE2 B:GLU161 5.0 35.4 1.0

R.Wang, C.Zhang, Y.Cao, J.Wang, S.Jiao, J.Zhang, M.Wang, P.Tang, Z.Ouyang, W.Liang, Y.Mao, A.Wang, G.Li, J.Zhang, M.Wang, S.Wang, X.Gui. Blockade of Dual Immune Checkpoint Inhibitory Signals with A CD47/Pd-L1 Bispecific Antibody For Cancer Treatment. Theranostics V. 13 148 2023.
ISSN: ISSN 1838-7640
PubMed: 36593962
DOI: 10.7150/THNO.79367