Chlorine in PDB 7yr3: Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2)

All present enzymatic activity of Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2):
3.4.17.23;

The structure of Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2) also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2) (pdb code 7yr3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2), PDB code: 7yr3:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl902 b:278.4 occ:1.00 NH2 D:ARG169 3.1 295.8 1.0 O D:ASP499 3.1 304.5 1.0 CZ2 D:TRP477 3.3 297.1 1.0 C D:ASP499 3.4 304.5 1.0 CA D:PRO500 3.5 296.6 1.0 N D:PRO500 3.6 296.6 1.0 CE2 D:TRP477 3.6 297.1 1.0 NE D:ARG169 3.7 295.8 1.0 NE1 D:TRP477 3.7 297.1 1.0 CZ D:ARG169 3.9 295.8 1.0 CB D:ASP499 4.0 304.5 1.0 CH2 D:TRP477 4.2 297.1 1.0 CA D:ASP499 4.3 304.5 1.0 C D:PRO500 4.4 296.6 1.0 CZ2 D:TRP478 4.5 297.8 1.0 CD D:PRO500 4.5 296.6 1.0 CB D:PRO500 4.6 296.6 1.0 O D:PRO500 4.6 296.6 1.0 CH2 D:TRP478 4.6 297.8 1.0 CD2 D:TRP477 4.7 297.1 1.0 OG D:SER502 4.7 293.3 1.0 CG D:PRO500 4.7 296.6 1.0 CD1 D:TRP477 4.8 297.1 1.0 CD1 D:LEU503 4.9 288.0 1.0 CD D:ARG169 5.0 295.8 1.0

Chlorine binding site 2 out of 2 in the Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Sars-Cov-2 Ba.2.75 S Trimer in Complex with ACE2(STATE2) within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl902 b:289.8 occ:1.00 NH1 G:ARG169 2.9 287.5 1.0 CZ G:ARG169 3.3 287.5 1.0 CD G:ARG169 3.4 287.5 1.0 NE G:ARG169 3.5 287.5 1.0 CZ2 G:TRP478 3.5 276.9 1.0 CH2 G:TRP478 3.8 276.9 1.0 CB G:ASP499 3.9 287.0 1.0 NE1 G:TRP165 3.9 284.9 1.0 CG G:ASP499 4.0 287.0 1.0 OD2 G:ASP499 4.1 287.0 1.0 NH2 G:ARG169 4.2 287.5 1.0 CZ2 G:TRP165 4.2 284.9 1.0 CE2 G:TRP165 4.4 284.9 1.0 CG G:ARG169 4.5 287.5 1.0 CE2 G:TRP478 4.5 276.9 1.0 OD1 G:ASP499 4.6 287.0 1.0 NE1 G:TRP477 4.7 282.9 1.0 CZ3 G:TRP271 4.7 282.0 1.0 CE3 G:TRP271 4.8 282.0 1.0 CA G:ASP499 5.0 287.0 1.0 CZ3 G:TRP478 5.0 276.9 1.0

Y.Cao, W.Song, L.Wang, P.Liu, C.Yue, F.Jian, Y.Yu, A.Yisimayi, P.Wang, Y.Wang, Q.Zhu, J.Deng, W.Fu, L.Yu, N.Zhang, J.Wang, T.Xiao, R.An, J.Wang, L.Liu, S.Yang, X.Niu, Q.Gu, F.Shao, X.Hao, B.Meng, R.K.Gupta, R.Jin, Y.Wang, X.S.Xie, X.Wang. Characterization of the Enhanced Infectivity and Antibody Evasion of Omicron Ba.2.75. Cell Host Microbe V. 30 1527 2022.
ISSN: ESSN 1934-6069
PubMed: 36270286
DOI: 10.1016/J.CHOM.2022.09.018