Chlorine in PDB 7z21: Baf A12T Bound to the Lamin A/C Ig-Fold Domain
Protein crystallography data
The structure of Baf A12T Bound to the Lamin A/C Ig-Fold Domain, PDB code: 7z21
was solved by
A.Marcelot,
P.Legrand,
S.Zinn-Justin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
14.90 /
1.63
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
63.11,
75.073,
65.034,
90,
114.19,
90
|
R / Rfree (%)
|
26.8 /
30
|
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Baf A12T Bound to the Lamin A/C Ig-Fold Domain
(pdb code 7z21). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the
Baf A12T Bound to the Lamin A/C Ig-Fold Domain, PDB code: 7z21:
Jump to Chlorine binding site number:
1;
2;
3;
4;
Chlorine binding site 1 out
of 4 in 7z21
Go back to
Chlorine Binding Sites List in 7z21
Chlorine binding site 1 out
of 4 in the Baf A12T Bound to the Lamin A/C Ig-Fold Domain
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Baf A12T Bound to the Lamin A/C Ig-Fold Domain within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl101
b:30.3
occ:1.00
|
H
|
A:GLY25
|
2.2
|
9.1
|
1.0
|
HG
|
A:SER4
|
2.2
|
15.6
|
1.0
|
O
|
A:HOH301
|
2.8
|
26.9
|
1.0
|
HA
|
A:ALA24
|
3.0
|
9.0
|
1.0
|
HB3
|
A:LYS6
|
3.2
|
17.0
|
1.0
|
OG
|
A:SER4
|
3.2
|
15.6
|
1.0
|
HD2
|
A:LYS6
|
3.2
|
25.3
|
1.0
|
N
|
A:GLY25
|
3.2
|
9.1
|
1.0
|
O
|
A:HOH213
|
3.3
|
22.1
|
1.0
|
HB3
|
A:SER4
|
3.5
|
15.6
|
1.0
|
O
|
A:HOH305
|
3.5
|
27.8
|
1.0
|
HB2
|
A:SER4
|
3.5
|
15.6
|
1.0
|
CB
|
A:SER4
|
3.6
|
15.6
|
1.0
|
O
|
A:HOH271
|
3.6
|
18.6
|
1.0
|
HB1
|
A:ALA24
|
3.7
|
9.1
|
1.0
|
HA2
|
A:GLY25
|
3.9
|
9.7
|
1.0
|
CA
|
A:ALA24
|
3.9
|
9.0
|
1.0
|
HB2
|
A:LYS6
|
4.0
|
17.0
|
1.0
|
HE3
|
A:LYS6
|
4.0
|
26.9
|
1.0
|
C
|
A:ALA24
|
4.0
|
8.8
|
1.0
|
CB
|
A:LYS6
|
4.0
|
17.0
|
1.0
|
HZ2
|
A:LYS6
|
4.1
|
26.5
|
1.0
|
CA
|
A:GLY25
|
4.1
|
9.7
|
1.0
|
CD
|
A:LYS6
|
4.2
|
25.3
|
1.0
|
O
|
A:HOH225
|
4.3
|
22.2
|
1.0
|
CB
|
A:ALA24
|
4.3
|
9.2
|
1.0
|
CE
|
A:LYS6
|
4.5
|
26.9
|
1.0
|
O
|
A:HOH256
|
4.6
|
20.6
|
1.0
|
HB3
|
A:ASP76
|
4.6
|
10.7
|
1.0
|
H
|
A:LYS6
|
4.6
|
14.6
|
1.0
|
O
|
A:HOH309
|
4.6
|
28.0
|
1.0
|
H
|
A:HIS7
|
4.6
|
11.3
|
1.0
|
O
|
A:HOH300
|
4.7
|
37.8
|
1.0
|
CG
|
A:LYS6
|
4.7
|
22.0
|
1.0
|
NZ
|
A:LYS6
|
4.8
|
26.5
|
1.0
|
HB2
|
A:ALA24
|
4.8
|
9.2
|
1.0
|
OD2
|
A:ASP76
|
4.9
|
18.2
|
1.0
|
H
|
A:ILE26
|
4.9
|
9.8
|
1.0
|
C
|
A:GLY25
|
4.9
|
10.4
|
1.0
|
O
|
E:HOH679
|
4.9
|
11.3
|
1.0
|
HD3
|
A:LYS6
|
5.0
|
25.3
|
1.0
|
HA3
|
A:GLY25
|
5.0
|
9.7
|
1.0
|
|
Chlorine binding site 2 out
of 4 in 7z21
Go back to
Chlorine Binding Sites List in 7z21
Chlorine binding site 2 out
of 4 in the Baf A12T Bound to the Lamin A/C Ig-Fold Domain
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Baf A12T Bound to the Lamin A/C Ig-Fold Domain within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl101
b:25.4
occ:1.00
|
H
|
B:GLY25
|
2.4
|
9.9
|
1.0
|
HG
|
B:SER4
|
2.4
|
15.6
|
1.0
|
HD3
|
B:LYS6
|
3.1
|
23.9
|
1.0
|
HB2
|
B:LYS6
|
3.2
|
16.1
|
1.0
|
HA
|
B:ALA24
|
3.3
|
10.2
|
1.0
|
OG
|
B:SER4
|
3.3
|
15.6
|
1.0
|
N
|
B:GLY25
|
3.4
|
9.9
|
1.0
|
O
|
B:HOH206
|
3.4
|
21.3
|
1.0
|
HE2
|
B:LYS6
|
3.5
|
25.1
|
1.0
|
O
|
B:HOH266
|
3.5
|
20.7
|
1.0
|
HB3
|
B:SER4
|
3.5
|
15.2
|
1.0
|
HB2
|
B:SER4
|
3.5
|
15.2
|
1.0
|
CB
|
B:SER4
|
3.7
|
15.2
|
1.0
|
HB1
|
B:ALA24
|
3.8
|
11.2
|
1.0
|
HA2
|
B:GLY25
|
3.9
|
10.3
|
1.0
|
CD
|
B:LYS6
|
4.0
|
23.9
|
1.0
|
O
|
B:HOH212
|
4.0
|
19.1
|
1.0
|
CA
|
B:ALA24
|
4.1
|
10.2
|
1.0
|
CE
|
B:LYS6
|
4.2
|
25.1
|
1.0
|
CA
|
B:GLY25
|
4.2
|
10.2
|
1.0
|
HZ2
|
B:LYS6
|
4.2
|
24.6
|
1.0
|
CB
|
B:LYS6
|
4.2
|
16.1
|
1.0
|
C
|
B:ALA24
|
4.2
|
9.8
|
1.0
|
CB
|
B:ALA24
|
4.5
|
11.0
|
1.0
|
HB3
|
B:LYS6
|
4.5
|
16.1
|
1.0
|
O
|
B:HOH259
|
4.5
|
19.2
|
1.0
|
H
|
B:LYS6
|
4.6
|
14.1
|
1.0
|
CG
|
B:LYS6
|
4.7
|
20.4
|
1.0
|
HB3
|
B:ASP76
|
4.7
|
10.9
|
1.0
|
NZ
|
B:LYS6
|
4.7
|
24.6
|
1.0
|
H
|
B:HIS7
|
4.8
|
11.6
|
1.0
|
HD2
|
B:LYS6
|
4.8
|
23.9
|
1.0
|
HB2
|
B:ALA24
|
4.9
|
11.2
|
1.0
|
OD2
|
B:ASP76
|
4.9
|
17.4
|
1.0
|
C
|
B:GLY25
|
5.0
|
11.0
|
1.0
|
HG3
|
B:LYS6
|
5.0
|
20.4
|
1.0
|
|
Chlorine binding site 3 out
of 4 in 7z21
Go back to
Chlorine Binding Sites List in 7z21
Chlorine binding site 3 out
of 4 in the Baf A12T Bound to the Lamin A/C Ig-Fold Domain
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Baf A12T Bound to the Lamin A/C Ig-Fold Domain within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Cl101
b:45.0
occ:1.00
|
HH22
|
C:ARG60
|
2.3
|
23.7
|
1.0
|
HH11
|
C:ARG75
|
2.4
|
34.9
|
1.0
|
HD3
|
C:ARG75
|
2.7
|
28.3
|
1.0
|
HH12
|
C:ARG60
|
2.7
|
23.3
|
1.0
|
NH2
|
C:ARG60
|
3.3
|
23.7
|
1.0
|
NH1
|
C:ARG75
|
3.3
|
34.9
|
1.0
|
NH1
|
C:ARG60
|
3.6
|
23.3
|
1.0
|
HH12
|
C:ARG75
|
3.8
|
34.9
|
1.0
|
CD
|
C:ARG75
|
3.8
|
28.3
|
1.0
|
CZ
|
C:ARG60
|
3.9
|
24.0
|
1.0
|
HB2
|
C:ARG75
|
4.0
|
19.3
|
1.0
|
HH21
|
C:ARG60
|
4.1
|
23.7
|
1.0
|
HD2
|
C:ARG75
|
4.2
|
28.3
|
1.0
|
HB1
|
C:ALA71
|
4.2
|
24.0
|
1.0
|
CZ
|
C:ARG75
|
4.3
|
34.7
|
1.0
|
HH11
|
C:ARG60
|
4.4
|
23.3
|
1.0
|
NE
|
C:ARG75
|
4.5
|
32.0
|
1.0
|
HG3
|
C:ARG75
|
4.5
|
23.6
|
1.0
|
CG
|
C:ARG75
|
4.6
|
23.6
|
1.0
|
O
|
C:HOH276
|
4.8
|
31.6
|
1.0
|
CB
|
C:ARG75
|
4.8
|
19.3
|
1.0
|
|
Chlorine binding site 4 out
of 4 in 7z21
Go back to
Chlorine Binding Sites List in 7z21
Chlorine binding site 4 out
of 4 in the Baf A12T Bound to the Lamin A/C Ig-Fold Domain
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Baf A12T Bound to the Lamin A/C Ig-Fold Domain within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Cl101
b:45.0
occ:1.00
|
HH12
|
D:ARG60
|
2.5
|
23.5
|
1.0
|
HH22
|
D:ARG60
|
2.7
|
22.8
|
1.0
|
HD3
|
D:ARG75
|
3.2
|
28.0
|
1.0
|
NH1
|
D:ARG60
|
3.4
|
23.5
|
1.0
|
NH2
|
D:ARG60
|
3.6
|
22.8
|
1.0
|
CZ
|
D:ARG60
|
4.0
|
23.7
|
1.0
|
HH11
|
D:ARG75
|
4.0
|
33.1
|
1.0
|
CD
|
D:ARG75
|
4.2
|
28.0
|
1.0
|
HH11
|
D:ARG60
|
4.2
|
23.5
|
1.0
|
HD2
|
D:ARG75
|
4.3
|
28.0
|
1.0
|
HH21
|
D:ARG60
|
4.4
|
22.8
|
1.0
|
HB2
|
D:ARG75
|
4.5
|
19.9
|
1.0
|
HG3
|
D:ARG75
|
4.7
|
24.1
|
1.0
|
HB1
|
D:ALA71
|
4.7
|
24.1
|
1.0
|
CG
|
D:ARG75
|
4.9
|
24.1
|
1.0
|
NH1
|
D:ARG75
|
5.0
|
33.1
|
1.0
|
|
Reference:
A.Janssen,
A.Marcelot,
S.Breusegem,
P.Legrand,
S.Zinn-Justin,
D.Larrieu.
The Baf A12T Mutation Disrupts Lamin A/C Interaction, Impairing Robust Repair of Nuclear Envelope Ruptures in Nestor-Guillermo Progeria Syndrome Cells. Nucleic Acids Res. V. 50 9260 2022.
ISSN: ESSN 1362-4962
PubMed: 36039758
DOI: 10.1093/NAR/GKAC726
Page generated: Tue Apr 4 22:22:12 2023
|