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Chlorine in PDB 8am0: Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
Enzymatic activity of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
All present enzymatic activity of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib):
2.7.1.137; 2.7.1.153; 2.7.11.1;
2.7.1.137; 2.7.1.153; 2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib), PDB code: 8am0
was solved by
M.Goncalves,
J.L.Johnson,
K.M.Roewer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.39 / 2.82 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 99.81, 107.68, 136.3, 90, 90, 90 |
| R / Rfree (%) | 28.5 / 30 |
Other elements in 8am0:
The structure of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib) also contains other interesting chemical elements:
| Fluorine | (F) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
(pdb code 8am0). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib), PDB code: 8am0:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib), PDB code: 8am0:
Chlorine binding site 1 out of 1 in 8am0
Go back to
Chlorine Binding Sites List in 8am0
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib) within 5.0Å range:
|
Reference:
T.Lin,
S.Ramsamooj,
K.Liberatore,
L.Lantier,
N.Vasan,
K.Karukurichi,
S.Hwang,
E.A.Kesicki,
E.R.Kastenhuber,
T.Wiederhold,
T.M.Yaron,
M.Zhu,
Y.Ma,
M.N.Paddock,
G.Zhang,
B.D.Hopkins,
O.Mcguinness,
R.E.Schwartz,
L.C.Cantley,
J.L.Johnson,
M.D.Goncalves.
Epinephrine Inhibits PI3K Alpha Via the Hippo Kinases To Be Published.
Page generated: Thu Dec 28 03:00:26 2023
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