Chlorine in PDB 8ayo: Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059

The structure of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

The binding sites of Chlorine atom in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 (pdb code 8ayo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059, PDB code: 8ayo:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:46.6 occ:1.00 CL A:CYZ902 0.0 46.6 1.0 C13 A:CYZ902 1.7 46.6 1.0 C14 A:CYZ902 2.7 46.6 1.0 C12 A:CYZ902 2.7 46.6 1.0 N3 A:CYZ902 3.0 46.6 1.0 S2 A:CYZ902 3.2 46.6 1.0 OD2 A:ASP756 3.3 53.9 1.0 CG A:ASP756 3.4 53.9 1.0 N A:ASP756 3.4 53.9 1.0 O4 A:CYZ902 3.5 46.6 1.0 OD1 A:ASP756 3.5 53.9 1.0 CB A:LEU755 3.6 53.1 1.0 C A:LEU755 3.6 53.1 1.0 CA A:ASP756 3.7 53.9 1.0 O A:LEU755 4.0 53.1 1.0 C11 A:CYZ902 4.0 46.6 1.0 C10 A:CYZ902 4.0 46.6 1.0 CB A:ASP756 4.1 53.9 1.0 CA A:LEU755 4.2 53.1 1.0 C9 A:CYZ902 4.5 46.6 1.0 O3 A:CYZ902 4.6 46.6 1.0 CG A:LEU755 4.8 53.1 1.0 CD1 A:LEU755 4.8 53.1 1.0 O A:PHE491 4.8 43.2 1.0

Chlorine binding site 2 out of 4 in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl902 b:55.1 occ:1.00 CL D:CYZ902 0.0 55.1 1.0 C13 D:CYZ902 1.7 55.1 1.0 N3 D:CYZ902 2.5 55.1 1.0 C14 D:CYZ902 2.7 55.1 1.0 C12 D:CYZ902 2.7 55.1 1.0 S2 D:CYZ902 3.2 55.1 1.0 N D:ASP760 3.8 59.0 1.0 C11 D:CYZ902 4.0 55.1 1.0 C10 D:CYZ902 4.0 55.1 1.0 CB D:LEU759 4.0 54.9 1.0 CA D:ASP760 4.0 59.0 1.0 O4 D:CYZ902 4.1 55.1 1.0 C D:LEU759 4.2 54.9 1.0 CB D:ASP760 4.3 59.0 1.0 O3 D:CYZ902 4.4 55.1 1.0 C9 D:CYZ902 4.5 55.1 1.0 CB C:SER725 4.5 57.6 1.0 O D:LEU759 4.5 54.9 1.0 O D:PHE495 4.7 43.4 1.0 CA D:LEU759 4.8 54.9 1.0 OG C:SER725 4.9 57.6 1.0 CG D:ASP760 5.0 59.0 1.0

Chlorine binding site 3 out of 4 in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:47.4 occ:1.00 CL C:CYZ902 0.0 47.4 1.0 C13 C:CYZ902 1.7 47.4 1.0 C14 C:CYZ902 2.7 47.4 1.0 C12 C:CYZ902 2.7 47.4 1.0 N3 C:CYZ902 2.9 47.4 1.0 S2 C:CYZ902 3.2 47.4 1.0 OD2 C:ASP756 3.3 53.5 1.0 CG C:ASP756 3.4 53.5 1.0 N C:ASP756 3.4 53.5 1.0 OD1 C:ASP756 3.5 53.5 1.0 O4 C:CYZ902 3.5 47.4 1.0 CB C:LEU755 3.6 53.1 1.0 C C:LEU755 3.6 53.1 1.0 CA C:ASP756 3.7 53.5 1.0 O C:LEU755 4.0 53.1 1.0 C11 C:CYZ902 4.0 47.4 1.0 C10 C:CYZ902 4.0 47.4 1.0 CB C:ASP756 4.1 53.5 1.0 CA C:LEU755 4.2 53.1 1.0 C9 C:CYZ902 4.5 47.4 1.0 O3 C:CYZ902 4.6 47.4 1.0 CG C:LEU755 4.8 53.1 1.0 CD1 C:LEU755 4.8 53.1 1.0 O C:PHE491 4.8 43.5 1.0

Chlorine binding site 4 out of 4 in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl902 b:55.3 occ:1.00 CL B:CYZ902 0.0 55.3 1.0 C13 B:CYZ902 1.7 55.3 1.0 N3 B:CYZ902 2.5 55.3 1.0 C14 B:CYZ902 2.7 55.3 1.0 C12 B:CYZ902 2.7 55.3 1.0 S2 B:CYZ902 3.2 55.3 1.0 N B:ASP760 3.8 59.0 1.0 C11 B:CYZ902 4.0 55.3 1.0 C10 B:CYZ902 4.0 55.3 1.0 CB B:LEU759 4.0 55.2 1.0 CA B:ASP760 4.0 59.0 1.0 O4 B:CYZ902 4.1 55.3 1.0 C B:LEU759 4.2 55.2 1.0 CB B:ASP760 4.3 59.0 1.0 O3 B:CYZ902 4.4 55.3 1.0 CB A:SER725 4.5 56.4 1.0 C9 B:CYZ902 4.5 55.3 1.0 O B:LEU759 4.5 55.2 1.0 O B:PHE495 4.7 43.5 1.0 CA B:LEU759 4.8 55.2 1.0 OG A:SER725 5.0 56.4 1.0 CG B:ASP760 5.0 59.0 1.0

D.Zhang, R.Lape, S.A.Shaikh, B.K.Kohegyi, J.F.Watson, O.Cais, T.Nakagawa, I.H.Greger. Modulatory Mechanisms of Tarp Gamma 8-Selective Ampa Receptor Therapeutics. Nat Commun V. 14 1659 2023.
ISSN: ESSN 2041-1723
PubMed: 36966141
DOI: 10.1038/S41467-023-37259-5