Chlorine in PDB 8b4x: X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol

Enzymatic activity of X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol

All present enzymatic activity of X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol:
3.4.21.75;

Protein crystallography data

The structure of X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol, PDB code: 8b4x was solved by S.O.Dahms, H.Brandstetter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.06 / 1.60
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 132.049, 132.049, 155.492, 90, 90, 120
R / Rfree (%) 15.8 / 17

Other elements in 8b4x:

The structure of X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol also contains other interesting chemical elements:

Calcium (Ca) 3 atoms
Sodium (Na) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol (pdb code 8b4x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol, PDB code: 8b4x:

Chlorine binding site 1 out of 1 in 8b4x

Go back to Chlorine Binding Sites List in 8b4x
Chlorine binding site 1 out of 1 in the X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Furin (PCSK3) in Complex with Guanidinomethyl-Phac- R-Tle-K-6-(Aminomethyl)-3-Amino-Isoindol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl608

b:22.1
occ:1.00
 HZ2 A:LYS449 2.3 24.5 1.0
HH A:TYR571 2.4 29.0 1.0
HE2 A:PHE275 3.1 60.4 1.0
HD2 A:LYS449 3.1 24.8 1.0
HE1 A:TYR571 3.1 23.9 1.0
NZ A:LYS449 3.1 20.4 1.0
OH A:TYR571 3.2 24.1 1.0
HZ1 A:LYS449 3.5 24.5 1.0
O A:HOH784 3.5 30.4 1.0
HH A:TYR313 3.5 36.1 1.0
HE3 A:LYS449 3.6 21.9 1.0
HZ3 A:LYS449 3.7 24.5 1.0
CE A:LYS449 3.7 18.2 1.0
CE1 A:TYR571 3.8 19.9 1.0
CD A:LYS449 3.8 20.6 1.0
OH A:TYR313 3.8 30.0 1.0
CZ A:TYR571 4.0 20.9 1.0
CE2 A:PHE275 4.0 50.3 1.0
O A:HOH1011 4.0 19.8 0.3
HD3 A:LYS449 4.3 24.8 1.0
HH22 A:ARG490 4.3 26.6 1.0
O A:HOH1011 4.3 18.7 0.7
HZ A:PHE275 4.4 36.8 1.0
CZ A:PHE275 4.7 30.6 1.0
HE2 A:LYS449 4.7 21.9 1.0
HG3 A:LYS449 4.9 23.8 1.0
HD2 A:PHE275 4.9 60.6 1.0
HB2 A:LYS449 4.9 22.3 1.0
HD11 A:ILE312 5.0 27.0 1.0
CG A:LYS449 5.0 19.8 1.0

Reference:

S.O.Dahms, H.Brandstetter. Aminoisoindol-Based Furin Inhibitors To Be Published.
Page generated: Tue Jul 30 07:01:18 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy