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Chlorine in PDB 8baj: Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-OneEnzymatic activity of Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One
All present enzymatic activity of Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One:
5.2.1.8; Protein crystallography data
The structure of Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One, PDB code: 8baj
was solved by
C.Meyners,
F.Hausch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One
(pdb code 8baj). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One, PDB code: 8baj: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 8bajGo back to Chlorine Binding Sites List in 8baj
Chlorine binding site 1 out
of 2 in the Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 8bajGo back to Chlorine Binding Sites List in 8baj
Chlorine binding site 2 out
of 2 in the Structure of the FK1 Domain of the FKBP51 G64S Variant in Complex with (1S,5S,6R)-10-((3,5-Dichlorophenyl)Sulfonyl)-5-(Hydroxymethyl)-3- (Pyridin-2-Ylmethyl)-3,10-Diazabicyclo[4.3.1]Decan-2-One
Mono view Stereo pair view
Reference:
J.A.Lerma Romero,
C.Meyners,
A.Christmann,
L.M.Reinbold,
A.Charalampidou,
F.Hausch,
H.Kolmar.
Binding Pocket Stabilization By High-Throughput Screening of Yeast Display Libraries. Front Mol Biosci V. 9 23131 2022.
Page generated: Tue Apr 4 22:32:31 2023
ISSN: ESSN 2296-889X PubMed: 36419931 DOI: 10.3389/FMOLB.2022.1023131 |
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