Chlorine in PDB 8bbw: Crystal Structure of Medical Leech Destabilase (Low Salt)

All present enzymatic activity of Crystal Structure of Medical Leech Destabilase (Low Salt):
3.2.1.17;

The structure of Crystal Structure of Medical Leech Destabilase (Low Salt), PDB code: 8bbw was solved by E.Marin, S.Bukhdruker, V.Manuvera, D.Kornilov, E.Zinovev, P.Bobrovsky, V.Lazarev, V.Borshchevskiy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.95 / 1.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	26.39, 35.87, 54.47, 90, 92.27, 90
R / Rfree (%)	15.4 / 19.3

The binding sites of Chlorine atom in the Crystal Structure of Medical Leech Destabilase (Low Salt) (pdb code 8bbw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Medical Leech Destabilase (Low Salt), PDB code: 8bbw:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Medical Leech Destabilase (Low Salt)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Medical Leech Destabilase (Low Salt) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl703 b:33.4 occ:1.00 N A:CYS105 3.3 12.5 1.0 CB A:THR104 3.5 15.2 1.0 N A:GLN106 3.6 13.1 1.0 CB A:CYS105 3.6 15.1 1.0 OG1 A:THR104 3.7 18.8 1.0 CA A:CYS105 3.9 13.5 1.0 O A:HOH852 3.9 25.6 1.0 O A:HOH831 4.1 33.4 1.0 CH2 A:TRP128 4.1 16.9 1.0 C A:CYS105 4.2 11.2 1.0 C A:THR104 4.2 11.6 1.0 CA A:THR104 4.4 12.4 1.0 CG2 A:THR104 4.5 16.0 1.0 CZ2 A:TRP128 4.5 19.2 1.0 CB A:GLN106 4.6 12.7 1.0 CA A:GLN106 4.7 12.6 1.0 CZ3 A:TRP128 5.0 15.7 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Medical Leech Destabilase (Low Salt)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Medical Leech Destabilase (Low Salt) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl704 b:17.3 occ:1.00 OG A:SER122 3.0 21.7 1.0 N A:ALA123 3.6 13.9 1.0 CA A:ALA123 3.7 11.9 1.0 C A:SER122 3.7 12.1 1.0 CB A:SER122 3.8 21.2 1.0 O A:SER122 3.9 14.4 1.0 CB A:ALA123 4.2 17.9 1.0 CA A:SER122 4.4 12.8 1.0 O A:HOH839 4.7 14.5 1.0 O A:HOH875 4.7 40.6 1.0 C A:ALA123 5.0 12.5 1.0

E.Marin, D.Kornilov, S.Bukhdruker, V.Manuvera, E.Zinovev, K.Kovalev, M.Shevtsov, A.Talyzina, P.Bobrovsky, P.Kuzmichev, A.Mishin, I.Gushchin, V.Gordeliy, V.Lazarev, V.Borshchevskiy. Structural Basis For Inhibition of Thrombolytic Destabilase From Medical Leech By Physiological Sodium Concentrations To Be Published.