Chlorine in PDB 8bik: Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455

All present enzymatic activity of Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455:
2.7.11.1; 2.7.11.27; 2.7.11.31;

The structure of Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455, PDB code: 8bik was solved by M.Schimpl, K.M.Mather, M.L.Boland, E.L.Rivers, A.Srivastava, P.Hemsley, J.Robinson, P.T.Wan, J.Hansen, J.A.Read, J.L.Trevaskis, D.M.Smith, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	69.52 / 2.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	75.313, 127.975, 139.215, 90, 92.91, 90
R / Rfree (%)	18.1 / 21.5

The binding sites of Chlorine atom in the Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455 (pdb code 8bik). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455, PDB code: 8bik:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1002 b:52.5 occ:1.00 CL A:QTN1002 0.0 52.5 1.0 C24 A:QTN1002 1.7 47.8 1.0 C23 A:QTN1002 2.7 45.1 1.0 C13 A:QTN1002 2.8 42.4 1.0 C9 A:QTN1002 2.9 40.5 1.0 C10 A:QTN1002 3.1 41.2 1.0 CZ A:PHE90 3.7 41.7 1.0 CG1 B:VAL81 3.7 42.1 1.0 CG2 B:VAL113 3.7 46.4 1.0 CD1 B:ILE115 3.8 39.6 1.0 CE2 A:PHE90 3.9 43.7 1.0 C22 A:QTN1002 4.0 46.1 1.0 N1 A:QTN1002 4.0 42.3 1.0 CG2 B:VAL81 4.1 42.9 1.0 C8 A:QTN1002 4.1 42.3 1.0 CG1 B:ILE115 4.3 43.0 1.0 C11 A:QTN1002 4.4 40.3 1.0 C14 A:QTN1002 4.4 45.0 1.0 CB B:VAL81 4.5 43.1 1.0 CG1 B:VAL113 4.7 45.9 1.0 CB B:VAL113 4.8 46.5 1.0 CD1 A:LEU18 4.8 40.4 1.0 CG1 A:VAL11 4.8 56.8 1.0 CE1 A:PHE90 4.9 41.0 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Ampk Heterotrimer in Complex with Allosteric Activator C455 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1002 b:57.3 occ:1.00 CL D:QTN1002 0.0 57.3 1.0 C24 D:QTN1002 1.7 52.8 1.0 C23 D:QTN1002 2.7 48.5 1.0 C13 D:QTN1002 2.7 52.6 1.0 C9 D:QTN1002 3.0 52.6 1.0 C10 D:QTN1002 3.1 52.6 1.0 CD1 E:ILE115 3.7 50.5 1.0 CG2 E:VAL113 3.7 60.6 1.0 CG1 E:VAL81 3.8 64.0 1.0 CZ D:PHE90 3.8 47.2 1.0 CE2 D:PHE90 3.9 48.2 1.0 C22 D:QTN1002 4.0 49.8 1.0 N1 D:QTN1002 4.0 52.0 1.0 C8 D:QTN1002 4.1 52.5 1.0 CG2 E:VAL81 4.2 65.0 1.0 CG1 E:ILE115 4.2 59.7 1.0 C11 D:QTN1002 4.4 49.9 1.0 C14 D:QTN1002 4.4 50.5 1.0 CD1 D:LEU18 4.6 49.6 1.0 CB E:VAL81 4.6 65.4 1.0 CG1 E:VAL113 4.7 60.6 1.0 CD1 D:ILE46 4.7 42.5 1.0 CG1 D:VAL11 4.7 67.9 1.0 CB E:VAL113 4.8 61.2 1.0

K.M.Mather, M.Schimpl, K.M.Mather, M.L.Boland, E.L.Rivers, A.Srivastava, P.Hemsley, J.Robinson, P.T.Wan, J.Hansen, J.A.Read, J.L.Trevaskis, D.M.Smith. N/A N/A.