Chlorine in PDB 8bzl: Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42

All present enzymatic activity of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42:
3.4.25.1;

The structure of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42, PDB code: 8bzl was solved by F.Henneberg, A.Chari, E.Jankowska, J.Witkowska, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	107.12 / 2.14
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	113.915, 203.262, 316.421, 90, 90, 90
R / Rfree (%)	19.6 / 22.6

The structure of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 also contains other interesting chemical elements:

Potassium	(K)	6 atoms
Magnesium	(Mg)	10 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 40; Page 5, Binding sites: 41 - 50; Page 6, Binding sites: 51 - 54;

Binding sites:

The binding sites of Chlorine atom in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 (pdb code 8bzl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 54 binding sites of Chlorine where determined in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42, PDB code: 8bzl:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ 3:Cl301 b:67.0 occ:1.00 NH1 3:ARG69 3.0 44.2 1.0 O 3:HOH467 3.2 43.6 1.0 NH1 3:ARG65 3.4 39.1 1.0 O 3:HOH491 3.5 69.1 1.0 CD 3:ARG65 3.7 38.1 1.0 CB 3:ARG65 3.8 38.1 1.0 CG 3:ARG65 3.9 38.3 1.0 CZ 3:ARG69 4.2 44.4 1.0 CD 3:ARG69 4.2 44.3 1.0 CZ 3:ARG65 4.3 38.8 1.0 NE 3:ARG65 4.4 38.4 1.0 C15 3:1PE303 4.5 72.1 1.0 O 3:ARG65 4.5 40.2 1.0 OH5 3:1PE303 4.5 74.7 1.0 C25 3:1PE303 4.5 74.4 1.0 CA 3:ARG65 4.6 38.7 1.0 NE 3:ARG69 4.6 45.1 1.0 CG 3:ARG69 4.8 44.4 1.0 C 3:ARG65 4.9 39.6 1.0

Chlorine binding site 2 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:56.8 occ:1.00 N A:SER6 3.2 40.6 1.0 O C:HOH432 3.3 48.8 1.0 CD2 A:PHE7 3.7 38.4 1.0 CE2 A:PHE7 3.8 38.5 1.0 CB A:SER6 3.8 41.2 1.0 CA A:TYR5 3.9 42.8 1.0 C A:TYR5 4.0 40.7 1.0 CA A:SER6 4.0 39.8 1.0 OG A:SER6 4.2 41.6 1.0 O A:GLY4 4.3 51.7 1.0 N A:PHE7 4.5 38.1 1.0 N B:SER2 4.5 50.6 1.0 CD1 C:TYR3 4.5 55.8 1.0 CB A:TYR5 4.6 41.1 1.0 C A:SER6 4.7 38.7 1.0 CD1 A:TYR5 4.7 42.2 1.0 CE1 C:TYR3 4.8 56.1 1.0 CG A:PHE7 4.9 37.9 1.0 N A:TYR5 4.9 45.5 1.0

Chlorine binding site 3 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:70.8 occ:1.00 N A:ARG219 3.6 42.6 1.0 CA A:ARG218 4.0 42.8 1.0 C A:ARG218 4.3 42.9 1.0 CB A:ARG219 4.3 42.7 1.0 CG A:PRO66 4.3 35.5 1.0 NH2 A:ARG219 4.4 38.8 1.0 CZ A:ARG219 4.4 38.7 1.0 CB A:ARG218 4.4 44.2 1.0 CA A:ARG219 4.6 43.6 1.0 CG A:ARG219 4.6 41.1 1.0 NH1 A:ARG219 4.6 37.1 1.0 CD A:PRO66 4.7 35.3 1.0 O H:HOH556 4.7 64.0 1.0 NE A:ARG219 4.7 40.4 1.0 CB A:PRO66 4.8 35.6 1.0 O A:PHE217 4.9 41.2 1.0

Chlorine binding site 4 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:63.4 occ:1.00 O H:HOH489 3.1 40.5 1.0 NH1 A:ARG90 3.1 28.2 1.0 O A:HOH451 3.3 37.6 1.0 ND1 A:HIS87 3.7 36.4 1.0 CD A:ARG90 3.7 27.8 1.0 CA A:HIS87 3.8 30.6 1.0 CB A:HIS87 3.8 31.7 1.0 NZ G:LYS116 3.9 42.0 1.0 O A:HOH463 4.0 51.1 1.0 OG H:SER69 4.1 34.8 1.0 CG A:HIS87 4.1 34.0 1.0 CZ A:ARG90 4.1 28.6 1.0 CB H:SER69 4.2 33.1 1.0 N A:HIS87 4.3 29.5 1.0 O G:HOH536 4.3 58.1 1.0 NE A:ARG90 4.4 28.2 1.0 CG1 A:VAL86 4.6 30.0 1.0 CA H:SER69 4.6 33.3 1.0 O A:HOH428 4.6 40.6 1.0 C A:VAL86 4.7 29.4 1.0 CE1 A:HIS87 4.8 36.7 1.0 O A:VAL86 4.8 29.1 1.0 CE G:LYS116 4.8 39.4 1.0 CG A:ARG90 4.9 28.0 1.0

Chlorine binding site 5 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl304 b:76.4 occ:1.00 O A:HOH416 2.8 24.8 1.0 O H:HOH465 2.9 41.3 1.0 O A:HOH453 3.1 53.3 1.0 CG2 A:THR68 3.7 35.4 1.0 CB A:THR68 3.9 36.6 1.0 CA A:PRO103 4.0 35.2 1.0 NE2 A:GLN94 4.0 33.6 1.0 CD1 A:TYR97 4.0 32.2 1.0 NZ A:LYS69 4.2 46.7 1.0 CB A:PRO103 4.2 36.1 1.0 CG A:TYR97 4.3 31.5 1.0 CB A:TYR97 4.4 30.2 1.0 O A:HOH489 4.6 63.7 1.0 O A:ALA93 4.7 29.9 1.0 CE1 A:TYR97 4.7 33.5 1.0 CG A:PRO103 4.7 37.4 1.0 OG1 A:THR68 4.7 37.3 1.0 N A:ILE104 4.8 32.6 1.0 OE2 H:GLU64 4.8 41.1 1.0 OE1 H:GLU64 4.8 39.0 1.0 N A:PRO103 4.9 36.7 1.0 C A:PRO103 5.0 34.3 1.0

Chlorine binding site 6 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl301 b:42.6 occ:1.00 CL B:CL302 3.0 63.0 1.0 O B:HOH474 3.1 45.3 1.0 NE2 B:GLN95 3.2 33.3 1.0 N B:GLU70 3.4 43.7 1.0 CB B:ASN69 3.6 39.3 1.0 CG B:GLU70 3.6 51.9 1.0 ND2 I:ASN71 3.9 30.9 1.0 CA B:ASN69 3.9 40.5 1.0 CB B:GLU70 4.0 48.2 1.0 O B:HOH475 4.1 59.5 1.0 C B:ASN69 4.1 42.3 1.0 CA B:GLU70 4.3 45.9 1.0 CD B:GLN95 4.4 33.4 1.0 CG I:ASN71 4.4 31.3 1.0 CD2 B:LEU98 4.4 32.3 1.0 OE1 B:GLN95 4.7 34.3 1.0 CG B:ASN69 4.7 39.7 1.0 O I:HOH483 4.7 35.2 1.0 CD B:GLU70 4.8 55.4 1.0 OE1 B:GLU70 4.8 55.5 1.0 CB I:ASN71 4.8 31.2 1.0 O B:HOH431 4.9 25.2 1.0 O B:HOH458 5.0 24.3 1.0 OD1 I:ASN71 5.0 31.5 1.0 O I:HOH494 5.0 41.2 1.0

Chlorine binding site 7 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl302 b:63.0 occ:1.00 O B:HOH458 2.8 24.3 1.0 O B:HOH475 2.9 59.5 1.0 CL B:CL301 3.0 42.6 1.0 CB B:PRO104 3.7 36.7 1.0 CA B:PRO104 3.7 36.0 1.0 CD2 B:LEU98 3.8 32.3 1.0 ND2 B:ASN69 4.0 38.9 1.0 CB B:ASN69 4.1 39.3 1.0 CB B:LEU98 4.2 31.1 1.0 CD1 B:LEU98 4.3 32.4 1.0 CG B:LEU98 4.3 32.0 1.0 CG B:ASN69 4.4 39.7 1.0 N B:PRO104 4.5 36.8 1.0 NE2 B:GLN95 4.5 33.3 1.0 N B:GLU70 4.7 43.7 1.0 N B:ILE105 4.7 34.2 1.0 C B:PRO104 4.8 35.3 1.0 CG B:PRO104 4.8 37.6 1.0 O B:ALA94 4.9 31.9 1.0 CB B:GLU70 4.9 48.2 1.0 CD B:PRO104 5.0 37.5 1.0

Chlorine binding site 8 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl301 b:73.3 occ:1.00 N C:GLY162 3.1 53.4 1.0 CG1 C:VAL26 3.5 51.5 1.0 O C:HOH409 3.6 45.3 1.0 CA C:ILE161 3.7 52.3 1.0 O C:HOH424 3.8 55.4 1.0 O C:GLY162 3.9 57.7 1.0 C C:ILE161 3.9 53.3 1.0 CA C:GLY162 4.0 54.6 1.0 CB C:ALA165 4.0 64.8 1.0 CB C:ILE161 4.1 50.0 1.0 C C:GLY162 4.4 57.0 1.0 CG2 C:ILE161 4.4 49.3 1.0 CB C:VAL26 4.6 51.6 1.0 CG C:LYS27 4.6 61.9 1.0 O C:VAL26 4.9 55.8 1.0 C C:VAL26 4.9 55.2 1.0 O C:ALA160 5.0 54.1 1.0 N C:LYS27 5.0 57.1 1.0

Chlorine binding site 9 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl302 b:85.5 occ:1.00 O C:HOH435 2.8 43.5 1.0 NE C:ARG117 3.1 46.7 1.0 NH1 C:ARG117 3.2 47.3 1.0 CZ C:ARG117 3.6 46.7 1.0 NH2 C:ARG86 3.7 43.6 1.0 CD1 C:LEU114 3.7 40.9 1.0 CE1 C:TYR118 4.2 38.3 1.0 CD C:ARG117 4.2 45.6 1.0 NH1 C:ARG124 4.3 49.3 1.0 NH1 C:ARG86 4.3 43.3 1.0 CZ C:ARG86 4.5 43.5 1.0 NH2 C:ARG117 4.9 47.1 1.0 CB C:ARG117 4.9 42.4 1.0 CD1 C:TYR118 4.9 38.3 1.0

Chlorine binding site 10 out of 54 in the Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Human 20S Proteasome in Complex with Peptide Activator Peptide BLM42 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl301 b:88.0 occ:1.00 O D:HOH425 3.3 46.8 1.0 N D:GLY171 3.4 63.2 1.0 OG D:SER174 3.4 68.1 1.0 CG2 D:ILE31 3.7 61.2 1.0 CE D:LYS32 3.8 67.8 1.0 O D:GLY171 3.8 66.7 1.0 CA D:ILE170 3.9 62.9 1.0 C D:ILE170 4.1 63.2 1.0 CB D:SER174 4.1 68.7 1.0 NZ D:LYS32 4.1 68.8 1.0 CB D:ILE170 4.2 61.6 1.0 CA D:GLY171 4.3 64.2 1.0 CB D:ILE31 4.4 61.0 1.0 C D:GLY171 4.4 65.8 1.0 CG2 D:ILE170 4.6 61.4 1.0 O D:ALA169 4.8 65.0 1.0 NH2 D:ARG168 4.9 67.4 1.0 CD D:LYS32 5.0 67.4 1.0

M.Gizynska, P.Karpowicz, D.Sowik, K.Trepczyk, J.Witkowska, F.Hennenberg, A.Chari, A.Gieldon, K.Pierzynowska, L.Gaffke, G.Wegrzyn, E.Jankowska. Peptidic, BLM10-Based Activators of Human 20S Proteasome in Vitro and in Cellulo Enhance Degradation of Proteins Connected with Neurodegeneration. To Be Published.