Chlorine in PDB 8c8s: Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21).

Enzymatic activity of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21).

All present enzymatic activity of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21).:
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21)., PDB code: 8c8s was solved by Y.Yosaatmadja, J.A.Newman, H.T.Baddock, M.Bielinski, F.Von Delft, C.Bountra, P.J.Mchugh, C.J.Schofield, O.Gileadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.37 / 1.80
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.684, 57.321, 113.73, 90, 90, 90
R / Rfree (%) 21.2 / 24.6

Other elements in 8c8s:

The structure of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21). also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21). (pdb code 8c8s). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21)., PDB code: 8c8s:

Chlorine binding site 1 out of 1 in 8c8s

Go back to Chlorine Binding Sites List in 8c8s
Chlorine binding site 1 out of 1 in the Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21).


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21). within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1101

b:57.9
occ:1.00
 CL1 A:U2O1101 0.0 57.9 1.0
C7 A:U2O1101 1.7 51.3 1.0
C6 A:U2O1101 2.7 46.5 1.0
C8 A:U2O1101 2.7 49.6 1.0
OG A:SER735 3.0 36.0 1.0
C9 A:U2O1101 4.0 49.7 1.0
C5 A:U2O1101 4.0 46.5 1.0
N A:ASP736 4.1 29.7 1.0
CB A:SER735 4.2 30.0 1.0
CB A:ASP736 4.4 29.3 1.0
OD1 A:ASP736 4.5 37.5 1.0
C10 A:U2O1101 4.5 51.0 1.0
CA A:ASP736 4.5 30.5 1.0
O A:HOH1287 4.5 40.7 1.0
C A:SER735 4.6 28.1 1.0
CG A:ASP736 4.8 43.7 1.0
CA A:SER735 4.9 30.3 1.0

Reference:

Y.Yosaatmadja, J.A.Newman, H.T.Baddock, M.Bielinski, F.Von Delft, C.Bountra, P.J.Mchugh, C.J.Schofield, O.Gileadi. Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with Hydroxamic Acid Inhibitor (Compound 21). To Be Published.
Page generated: Tue Jul 30 07:47:59 2024

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