Chlorine in PDB 8c9g: Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin

Enzymatic activity of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin

All present enzymatic activity of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin:
6.1.1.5;

Protein crystallography data

The structure of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin, PDB code: 8c9g was solved by A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.39 / 2.80
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 66.82, 144.28, 108.37, 90, 95.64, 90
R / Rfree (%) 20 / 25.8

Other elements in 8c9g:

The structure of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin also contains other interesting chemical elements:

Sodium (Na) 3 atoms
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin (pdb code 8c9g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin, PDB code: 8c9g:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 8c9g

Go back to Chlorine Binding Sites List in 8c9g
Chlorine binding site 1 out of 4 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1003

b:60.9
occ:1.00
 NZ A:LYS430 3.1 32.8 1.0
CE A:LYS430 3.6 37.6 1.0
CG1 A:VAL432 4.3 51.9 1.0
O A:SER697 4.8 39.0 1.0

Chlorine binding site 2 out of 4 in 8c9g

Go back to Chlorine Binding Sites List in 8c9g
Chlorine binding site 2 out of 4 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1004

b:74.3
occ:1.00
 NH2 A:ARG447 3.2 75.1 1.0
CE2 A:TRP450 3.7 66.4 1.0
CD2 A:TRP450 3.8 68.2 1.0
ND2 A:ASN563 3.9 63.6 1.0
NE1 A:TRP450 4.0 68.0 1.0
CZ2 A:TRP450 4.1 61.2 1.0
CZ A:ARG447 4.1 79.1 1.0
CG A:TRP450 4.1 69.0 1.0
CE3 A:TRP450 4.1 59.4 1.0
CD1 A:TRP450 4.3 67.7 1.0
NH1 A:ARG447 4.3 79.2 1.0
CB A:SER564 4.4 53.1 1.0
CH2 A:TRP450 4.4 58.5 1.0
O A:ARG559 4.4 82.4 1.0
CZ3 A:TRP450 4.4 55.3 1.0
CG A:ASN563 4.6 66.7 1.0
CA A:SER564 4.6 57.5 1.0
N A:SER564 4.7 57.7 1.0
CB A:ALA197 4.9 72.1 1.0
CB A:TRP450 4.9 65.1 1.0
CB A:ASN563 5.0 67.8 1.0

Chlorine binding site 3 out of 4 in 8c9g

Go back to Chlorine Binding Sites List in 8c9g
Chlorine binding site 3 out of 4 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1005

b:67.3
occ:1.00
 NZ B:LYS686 3.2 52.9 1.0
CD B:LYS686 3.3 73.0 1.0
CE B:LYS686 3.7 71.5 1.0
OD2 B:ASP689 4.0 86.2 1.0
CA B:LYS686 4.6 58.5 1.0
CG B:LYS686 4.7 58.9 1.0
O B:ASN685 4.7 63.1 1.0
OE1 B:GLU788 4.7 105.2 1.0
CG B:ASP689 4.8 83.0 1.0
N B:LYS686 4.9 60.1 1.0
C B:ASN685 4.9 64.4 1.0
CB B:ASP689 5.0 69.5 1.0

Chlorine binding site 4 out of 4 in 8c9g

Go back to Chlorine Binding Sites List in 8c9g
Chlorine binding site 4 out of 4 in the Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Priestia Megaterium Mupirocin-Sensitive Isoleucyl-Trna Synthetase 1 Complexed with Mupirocin within 5.0Å range:

Reference:

A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj. Antibiotic Hyper-Resistance in A Class I Aminoacyl-Trna Synthetase with Altered Active Site Signature Motif To Be Published.
Page generated: Tue Jul 30 07:48:29 2024

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