Chlorine in PDB 8cz9: Crystal Structure of the E372K Lnk SH2 Domain Mutant in Complex with A JAK2 PY813 Phosphopeptide

The structure of Crystal Structure of the E372K Lnk SH2 Domain Mutant in Complex with A JAK2 PY813 Phosphopeptide, PDB code: 8cz9 was solved by R.Morris, N.J.Kershaw, J.J.Babon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.90 / 1.65
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	75.829, 37.618, 50.497, 90, 108.76, 90
R / Rfree (%)	18.5 / 21.6

The binding sites of Chlorine atom in the Crystal Structure of the E372K Lnk SH2 Domain Mutant in Complex with A JAK2 PY813 Phosphopeptide (pdb code 8cz9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the E372K Lnk SH2 Domain Mutant in Complex with A JAK2 PY813 Phosphopeptide, PDB code: 8cz9:

Chlorine binding site 1 out of 1 in the Crystal Structure of the E372K Lnk SH2 Domain Mutant in Complex with A JAK2 PY813 Phosphopeptide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the E372K Lnk SH2 Domain Mutant in Complex with A JAK2 PY813 Phosphopeptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:67.4 occ:1.00 C A:PHE403 3.6 28.3 1.0 N A:PRO404 3.7 30.7 1.0 CD A:PRO404 3.9 33.0 1.0 CA A:PHE403 4.0 27.4 1.0 O A:HIS402 4.0 35.2 1.0 O A:PHE403 4.0 33.0 1.0 N A:PHE403 4.0 32.8 1.0 C A:HIS402 4.0 28.2 1.0 OE1 A:GLN395 4.2 65.9 1.0 CA A:PRO404 4.2 36.4 1.0 CB A:HIS402 4.2 31.8 1.0 CB A:PRO404 4.6 37.0 1.0 CA A:HIS402 4.8 25.6 1.0 CG A:PRO404 4.8 44.7 1.0 O A:HOH606 5.0 54.4 1.0

Y.Zhang, R.Morris, A.M.Lorenzo, X.Meng, G.B.Brown, P.Kiridena, G.Burgio, A.Hatch, J.Cappello, Q.Shen, H.Wang, M.Stanley, Z.Yu, A.Headley, P.Tmka, D.Mallon, J.T.Fletcher, M.Sestan, M.Jelusic, M.M.Cook, D.A.Fulcher, V.Athanasopoulos, J.J.Babon, N.J.Kershaw, C.G.Vinuesa, J.I.Ellyard. Rare Genetic Variants in SH2B3 Identified in Lupus Patients Breach B Cell Tolerance and Predispose Carriers to Autoimmunity To Be Published.