Chlorine in PDB 8d5g: Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate

The structure of Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate, PDB code: 8d5g was solved by P.J.Stogios, T.Skarina, R.Di Leo, A.Savchenko, A.Joachimiak, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.82 / 2.78
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	101.54, 101.54, 207.009, 90, 90, 120
R / Rfree (%)	20.6 / 24.6

The binding sites of Chlorine atom in the Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate (pdb code 8d5g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate, PDB code: 8d5g:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:68.0 occ:1.00 O A:HOH418 3.5 31.1 1.0 CB A:SER216 3.8 50.1 1.0 NH1 A:ARG229 3.8 43.1 1.0 NE2 A:HIS182 4.0 47.0 1.0 NH2 A:ARG229 4.1 49.1 1.0 CA A:SER216 4.1 43.3 1.0 O A:HOH434 4.3 45.4 1.0 CZ A:ARG229 4.4 46.8 1.0 N A:SER216 4.4 44.0 1.0 O B:HOH457 4.5 47.6 1.0 CD2 A:HIS182 4.7 46.6 1.0 OG A:SER216 4.9 58.9 1.0

Chlorine binding site 2 out of 4 in the Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:56.9 occ:1.00 O A:HOH413 3.3 40.3 1.0 N A:VAL147 3.4 39.8 1.0 CG2 A:VAL147 3.8 31.6 1.0 CA A:TYR146 4.0 38.8 1.0 CB A:VAL147 4.1 34.5 1.0 C A:TYR146 4.2 40.0 1.0 CA A:VAL147 4.4 44.4 1.0 O A:GLN145 4.5 40.9 1.0 OG1 A:THR152 4.7 40.6 1.0 CB A:TYR146 4.7 43.3 1.0 CD2 A:TYR146 4.7 44.0 1.0

Chlorine binding site 3 out of 4 in the Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl304 b:78.3 occ:1.00 NH2 A:ARG151 4.0 58.0 1.0 CZ A:ARG151 4.2 67.9 1.0 CA A:ARG151 4.4 48.8 1.0 NH1 A:ARG151 4.6 62.9 1.0 NE A:ARG151 4.6 67.5 1.0 CB A:ARG151 4.6 51.5 1.0 CG1 A:VAL150 4.6 37.5 1.0 CG A:TYR154 4.7 51.9 1.0 CB A:TYR154 4.7 51.5 1.0 N A:ARG151 4.7 45.7 1.0 CD2 A:TYR154 4.8 59.8 1.0 O A:VAL150 5.0 46.1 1.0

Chlorine binding site 4 out of 4 in the Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Dihydropteroate Synthase (Folp-SMZ_B27) From Soil Uncultured Bacterium in Complex with 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphate within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl302 b:69.7 occ:1.00 CG B:TYR154 4.9 35.1 1.0 CD1 B:TYR154 4.9 33.5 1.0

P.J.Stogios, P.J.Stogios, T.Skarina, R.Di Leo, A.Savchenko, A.Joachimiak, K.J.F.Satchell, Center For Structural Genomics Of Infectious Diseases(Csgid). N/A N/A.