Chlorine in PDB 8do3: Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I

The binding sites of Chlorine atom in the Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I (pdb code 8do3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I, PDB code: 8do3:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:62.0 occ:1.00 CL A:SWR501 0.0 62.0 1.0 C16 A:SWR501 1.7 62.0 1.0 C15 A:SWR501 2.7 62.0 1.0 C17 A:SWR501 2.7 62.0 1.0 H13 A:SWR501 2.8 62.0 1.0 H14 A:SWR501 2.8 62.0 1.0 C14 A:SWR501 4.0 62.0 1.0 C18 A:SWR501 4.0 62.0 1.0 C13 A:SWR501 4.5 62.0 1.0 H12 A:SWR501 4.8 62.0 1.0 H15 A:SWR501 4.8 62.0 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of the Human SEC61 Complex Inhibited By Eeyarestatin I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:62.0 occ:1.00 CL1 A:SWR501 0.0 62.0 1.0 C23 A:SWR501 1.7 62.0 1.0 C24 A:SWR501 2.7 62.0 1.0 C22 A:SWR501 2.7 62.0 1.0 H19 A:SWR501 2.8 62.0 1.0 H18 A:SWR501 2.8 62.0 1.0 CB A:VAL130 3.1 61.9 1.0 CG1 A:VAL130 3.1 61.9 1.0 CD1 A:TYR131 3.2 62.7 1.0 CA A:GLN127 3.2 60.9 1.0 O A:GLN127 3.2 60.9 1.0 CE1 A:TYR131 3.2 62.7 1.0 CB A:GLN127 3.5 60.9 1.0 CG A:GLN127 3.6 60.9 1.0 C A:GLN127 3.7 60.9 1.0 CG2 A:VAL130 3.9 61.9 1.0 C25 A:SWR501 4.0 62.0 1.0 C21 A:SWR501 4.0 62.0 1.0 N A:TYR131 4.2 62.7 1.0 CA A:VAL130 4.2 61.9 1.0 CD A:GLN127 4.3 60.9 1.0 N A:GLN127 4.4 60.9 1.0 C A:VAL130 4.5 61.9 1.0 CG A:TYR131 4.5 62.7 1.0 C20 A:SWR501 4.5 62.0 1.0 O A:GLY126 4.5 60.8 1.0 CZ A:TYR131 4.6 62.7 1.0 N A:VAL130 4.7 61.9 1.0 OE1 A:GLN127 4.7 60.9 1.0 CZ A:PHE62 4.8 63.0 1.0 H20 A:SWR501 4.8 62.0 1.0 H17 A:SWR501 4.8 62.0 1.0 C A:GLY126 4.9 60.8 1.0 N A:SER128 5.0 60.4 1.0

S.Itskanov, L.Wang, T.Junne, R.Sherriff, L.Xiao, N.Blanchard, W.Q.Shi, C.Forsyth, D.Hoepfner, M.Spiess, E.Park. A Common Mechanism of SEC61 Translocon Inhibition By Small Molecules. Nat.Chem.Biol. 2023.
ISSN: ESSN 1552-4469
PubMed: 37169959
DOI: 10.1038/S41589-023-01337-Y