Chlorine in PDB 8dpf: Cryo-Em Structure of the 5HT2C Receptor (Ini Isoform) Bound to Lorcaserin

The binding sites of Chlorine atom in the Cryo-Em Structure of the 5HT2C Receptor (Ini Isoform) Bound to Lorcaserin (pdb code 8dpf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Cryo-Em Structure of the 5HT2C Receptor (Ini Isoform) Bound to Lorcaserin, PDB code: 8dpf:

Chlorine binding site 1 out of 1 in the Cryo-Em Structure of the 5HT2C Receptor (Ini Isoform) Bound to Lorcaserin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of the 5HT2C Receptor (Ini Isoform) Bound to Lorcaserin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:57.5 occ:1.00 CL12 A:T4U501 0.0 57.5 1.0 C10 A:T4U501 1.8 57.5 1.0 C06 A:T4U501 2.8 57.5 1.0 C03 A:T4U501 2.8 57.5 1.0 H061 A:T4U501 2.9 57.5 1.0 H031 A:T4U501 2.9 57.5 1.0 OG A:SER219 3.7 60.6 1.0 N A:SER219 3.9 60.6 1.0 C A:GLY218 3.9 64.0 1.0 CA A:SER219 4.0 60.6 1.0 O A:GLY218 4.1 64.0 1.0 C02 A:T4U501 4.1 57.5 1.0 CE2 A:PHE214 4.1 69.3 1.0 C11 A:T4U501 4.1 57.5 1.0 CB A:SER219 4.4 60.6 1.0 CB A:ALA222 4.5 57.1 1.0 CA A:GLY218 4.5 64.0 1.0 C09 A:T4U501 4.6 57.5 1.0 CZ A:PHE214 4.6 69.3 1.0 CD2 A:PHE214 4.7 69.3 1.0 CG1 A:VAL135 4.8 54.7 1.0 CE1 A:PHE328 4.9 52.5 1.0 H021 A:T4U501 4.9 57.5 1.0 H013 A:T4U501 5.0 57.5 1.0

R.H.Gumpper, J.F.Fay, B.L.Roth. Molecular Insights Into the Regulation of Constitutive Activity By Rna Editing of 5HT 2C Serotonin Receptors. Cell Rep V. 40 11211 2022.
ISSN: ESSN 2211-1247
PubMed: 35977511
DOI: 10.1016/J.CELREP.2022.111211