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Chlorine in PDB 8ejb: Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-CarboxamideEnzymatic activity of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide
All present enzymatic activity of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide:
2.7.10.2; Protein crystallography data
The structure of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide, PDB code: 8ejb
was solved by
S.Gajewski,
M.C.Clifton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8ejb:
The structure of Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide
(pdb code 8ejb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide, PDB code: 8ejb: Chlorine binding site 1 out of 1 in 8ejbGo back to Chlorine Binding Sites List in 8ejb
Chlorine binding site 1 out
of 1 in the Bruton'S Tyrosine Kinase in Complex with 3-{[4-(1-Acetylpiperidin-4- Yl)Phenyl]Amino}-5-[(3R)-3-(3-Methyl-2-Oxoimidazolidin-1-Yl) Piperidin-1-Yl]Pyrazine-2-Carboxamide
Mono view Stereo pair view
Reference:
D.Zhang,
H.M.Harris,
J.Chen,
J.T.Judy,
G.James,
A.Kelly,
J.Mcintosh,
A.Tenn-Mcclellan,
E.R.Ambing,
Y.S.Tan,
H.Lu,
S.Gajewski,
M.C.Clifton,
S.Yung,
D.W.Robbins,
M.Piroozia,
S.S.Skanland,
E.M.Gaglione,
M.Mhibik,
C.Underbayev,
I.Ahn,
C.Sun,
S.E.M.Herman,
M.A.Noviski,
A.Wiestner.
-----Nrx-0492 Degrades Wildtype and C481 Mutant Btk and Demonstrates in Vivo Activity in Cll Patient Derived Xenografts. Blood 2022.
Page generated: Tue Apr 4 22:50:33 2023
ISSN: ESSN 1528-0020 PubMed: 36375120 DOI: 10.1182/BLOOD.2022016934 |
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