Chlorine in PDB 8ejm: Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch

All present enzymatic activity of Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch:
3.6.4.13;

The structure of Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch, PDB code: 8ejm was solved by J.Huang, L.Tong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.67 / 1.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	82.3, 90.956, 213.187, 90, 90, 90
R / Rfree (%)	18.9 / 22.4

The structure of Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Chlorine atom in the Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch (pdb code 8ejm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch, PDB code: 8ejm:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl807 b:79.4 occ:1.00 NH1 A:ARG204 3.4 41.4 1.0 NH2 A:ARG204 3.6 38.3 1.0 NH2 A:ARG126 3.6 69.3 1.0 NH1 A:ARG126 3.9 59.5 1.0 CZ A:ARG204 4.0 44.2 1.0 CZ A:ARG126 4.2 68.8 1.0 CG1 A:ILE130 4.4 42.6 1.0 CA A:ILE130 4.9 46.1 1.0 CG A:LYS133 4.9 62.4 1.0 CG2 A:ILE130 4.9 38.2 1.0 CB A:ILE130 5.0 44.9 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Deah-Box Helicase DHX15 in Complex with SUGP1 G-Patch within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl808 b:76.7 occ:1.00 NZ A:LYS714 3.2 45.9 1.0 NH1 A:ARG452 3.3 48.4 1.0 CD A:LYS714 3.5 53.0 1.0 OH A:TYR545 3.6 46.4 1.0 NH2 A:ARG452 3.8 63.7 1.0 CE A:LYS714 3.8 45.8 1.0 CZ A:ARG452 4.0 62.0 1.0 O A:HOH1134 4.1 52.1 1.0 O A:HOH1033 4.5 52.0 1.0 CE1 A:TYR765 4.5 38.2 1.0 CZ A:TYR545 4.6 44.0 1.0 CE2 A:TYR545 4.8 38.5 1.0 CG A:LYS714 4.9 52.6 1.0 CD1 A:TYR765 5.0 36.0 1.0

J.Zhang, J.Huang, K.Xu, P.Xing, Y.Huang, Z.Liu, L.Tong, J.L.Manley. DHX15 Is Involved in SUGP1-Mediated Rna Missplicing By Mutant SF3B1 in Cancer. Proc.Natl.Acad.Sci.Usa V. 119 12119 2022.
ISSN: ESSN 1091-6490
PubMed: 36459648
DOI: 10.1073/PNAS.2216712119