Chlorine in PDB 8est: Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin
Enzymatic activity of Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin
All present enzymatic activity of Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin:
3.4.21.36;
3.4.21.36;
Protein crystallography data
The structure of Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin, PDB code: 8est
was solved by
R.Radhakrishnan,
J.C.Powers,
E.F.Meyerjunior,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 7.00 / 1.78 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 50.620, 58.260, 75.240, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17 / n/a |
Other elements in 8est:
The structure of Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin also contains other interesting chemical elements:
| Calcium | (Ca) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin
(pdb code 8est). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin, PDB code: 8est:
In total only one binding site of Chlorine was determined in the Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin, PDB code: 8est:
Chlorine binding site 1 out of 1 in 8est
Go back to
Chlorine Binding Sites List in 8est
Chlorine binding site 1 out
of 1 in the Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4- Chloro-3-Ethoxy-7-Guanidino-Isocoumarin within 5.0Å range:
|
Reference:
J.C.Powers,
J.Oleksyszyn,
S.L.Narasimhan,
C.M.Kam.
Reaction of Porcine Pancreatic Elastase with 7-Substituted 3-Alkoxy-4-Chloroisocoumarins: Design of Potent Inhibitors Using the Crystal Structure of the Complex Formed with 4-Chloro-3-Ethoxy-7-Guanidinoisocoumarin. Biochemistry V. 29 3108 1990.
ISSN: ISSN 0006-2960
PubMed: 2337582
DOI: 10.1021/BI00464A030
Page generated: Sun Dec 13 10:33:48 2020
ISSN: ISSN 0006-2960
PubMed: 2337582
DOI: 10.1021/BI00464A030
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