Chlorine in PDB 8f0q: Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310

The structure of Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310 also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Chlorine atom in the Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310 (pdb code 8f0q). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310, PDB code: 8f0q:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1604 b:40.9 occ:1.00 CL01 A:X7R1604 0.0 40.9 1.0 C22 A:X7R1604 1.7 19.0 1.0 C23 A:X7R1604 2.7 17.6 1.0 C21 A:X7R1604 2.7 15.8 1.0 CD2 A:LEU1250 3.8 17.0 1.0 C24 A:X7R1604 4.0 16.2 1.0 C20 A:X7R1604 4.0 16.0 1.0 C25 A:X7R1604 4.5 15.9 1.0 CG A:LEU1250 4.8 16.2 1.0

Chlorine binding site 2 out of 2 in the Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of VSD4-NAV1.7-Navpas Channel Chimera Bound to the Acylsulfonamide Inhibitor Gdc-0310 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1604 b:41.4 occ:1.00 CL02 A:X7R1604 0.0 41.4 1.0 C24 A:X7R1604 1.7 16.2 1.0 C25 A:X7R1604 2.7 15.9 1.0 C23 A:X7R1604 2.7 17.6 1.0 C22 A:X7R1604 4.0 19.0 1.0 C20 A:X7R1604 4.0 16.0 1.0 C21 A:X7R1604 4.5 15.8 1.0

M.Kschonsak, C.C.Jao, C.P.Arthur, A.L.Rohou, P.Bergeron, D.F.Ortwine, S.J.Mckerrall, D.H.Hackos, L.Deng, J.Chen, T.Li, P.S.Dragovich, M.Volgraf, M.R.Wright, J.Payandeh, C.Ciferri, J.C.Tellis. Cryo-Em Reveals An Unprecedented Binding Site For Na V 1.7 Inhibitors Enabling Rational Design of Potent Hybrid Inhibitors. Elife V. 12 2023.
ISSN: ESSN 2050-084X
PubMed: 36975198
DOI: 10.7554/ELIFE.84151