Chlorine in PDB 8fhn: Cryo-Em Structure of Human Ncc (Class 2)

The structure of Cryo-Em Structure of Human Ncc (Class 2) also contains other interesting chemical elements:

Fluorine

(F)

6 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Ncc (Class 2) (pdb code 8fhn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Ncc (Class 2), PDB code: 8fhn:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc (Class 2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Ncc (Class 2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1102 b:22.0 occ:1.00 CL01 A:XZF1102 0.0 22.0 1.0 C23 A:XZF1102 1.8 22.0 1.0 C22 A:XZF1102 2.7 22.0 1.0 C21 A:XZF1102 2.7 22.0 1.0 O10 A:XZF1102 2.9 22.0 1.0 S04 A:XZF1102 3.1 22.0 1.0 O11 A:XZF1102 3.1 22.0 1.0 CB A:LEU355 3.4 19.3 1.0 CD1 A:LEU355 3.4 19.3 1.0 CZ A:PHE223 3.5 20.8 1.0 CG A:LEU355 3.8 19.3 1.0 CE1 A:PHE223 3.9 20.8 1.0 C20 A:XZF1102 4.0 22.0 1.0 N A:LEU355 4.0 19.3 1.0 C17 A:XZF1102 4.1 22.0 1.0 CA A:LEU355 4.1 19.3 1.0 C A:LEU355 4.4 19.3 1.0 C16 A:XZF1102 4.5 22.0 1.0 CA A:GLY353 4.5 19.1 1.0 CE2 A:PHE223 4.6 20.8 1.0 CD1 A:PHE536 4.6 21.2 1.0 O A:LEU355 4.7 19.3 1.0 CE1 A:PHE536 4.7 21.2 1.0 C A:GLY353 4.7 19.1 1.0 N14 A:XZF1102 4.8 22.0 1.0 N A:ILE354 4.8 18.7 1.0 ND2 A:ASN359 4.9 21.2 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc (Class 2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Ncc (Class 2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1102 b:33.0 occ:1.00 CL01 B:XZF1102 0.0 33.0 1.0 C23 B:XZF1102 1.8 33.0 1.0 C21 B:XZF1102 2.7 33.0 1.0 C22 B:XZF1102 2.8 33.0 1.0 O11 B:XZF1102 2.8 33.0 1.0 S04 B:XZF1102 3.3 33.0 1.0 CB B:LEU355 3.4 28.9 1.0 CD1 B:LEU355 3.4 28.9 1.0 CZ B:PHE223 3.7 23.4 1.0 CG B:LEU355 3.8 28.9 1.0 CE1 B:PHE223 3.8 23.4 1.0 O10 B:XZF1102 3.8 33.0 1.0 CD2 B:LEU355 4.0 28.9 1.0 C17 B:XZF1102 4.0 33.0 1.0 C20 B:XZF1102 4.0 33.0 1.0 N B:LEU355 4.0 28.9 1.0 OH B:TYR540 4.1 24.8 1.0 CA B:LEU355 4.3 28.9 1.0 CA B:GLY353 4.3 30.8 1.0 CE1 B:TYR540 4.3 24.8 1.0 C16 B:XZF1102 4.5 33.0 1.0 C B:GLY353 4.6 30.8 1.0 N B:GLY353 4.6 30.8 1.0 N B:ILE354 4.6 29.8 1.0 CD1 B:PHE536 4.7 28.5 1.0 CZ B:TYR540 4.7 24.8 1.0 N14 B:XZF1102 4.8 33.0 1.0 CE1 B:PHE536 4.9 28.5 1.0 C B:LEU355 4.9 28.9 1.0 CE2 B:PHE223 4.9 23.4 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0