Chlorine in PDB 8fho: Cryo-Em Structure of Human Ncc (Class 1)

The structure of Cryo-Em Structure of Human Ncc (Class 1) also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Sodium	(Na)	2 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Ncc (Class 1) (pdb code 8fho). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Ncc (Class 1), PDB code: 8fho:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1102 b:31.4 occ:1.00 CL01 A:XZF1102 0.0 31.4 1.0 C23 A:XZF1102 1.8 31.4 1.0 C21 A:XZF1102 2.7 31.4 1.0 C22 A:XZF1102 2.7 31.4 1.0 CD1 A:LEU355 2.9 26.8 1.0 O10 A:XZF1102 3.0 31.4 1.0 O11 A:XZF1102 3.1 31.4 1.0 S04 A:XZF1102 3.1 31.4 1.0 CG A:LEU355 3.2 26.8 1.0 CB A:LEU355 3.4 26.8 1.0 N A:LEU355 3.8 26.8 1.0 CZ A:PHE223 3.8 26.4 1.0 CA A:GLY353 3.9 28.3 1.0 C20 A:XZF1102 4.0 31.4 1.0 C17 A:XZF1102 4.0 31.4 1.0 CE1 A:PHE223 4.1 26.4 1.0 C A:GLY353 4.1 28.3 1.0 CA A:LEU355 4.1 26.8 1.0 N A:ILE354 4.3 26.0 1.0 CE1 A:TYR540 4.4 23.3 1.0 N A:GLY353 4.4 28.3 1.0 C16 A:XZF1102 4.5 31.4 1.0 OH A:TYR540 4.6 23.3 1.0 CD1 A:PHE536 4.6 27.6 1.0 CD2 A:LEU355 4.6 26.8 1.0 O A:GLY353 4.6 28.3 1.0 CE1 A:PHE536 4.8 27.6 1.0 C A:LEU355 4.8 26.8 1.0 N14 A:XZF1102 4.8 31.4 1.0 C A:ILE354 4.9 26.0 1.0 CE2 A:PHE223 5.0 26.4 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1102 b:46.8 occ:1.00 CL01 B:XZF1102 0.0 46.8 1.0 C23 B:XZF1102 1.8 46.8 1.0 C22 B:XZF1102 2.7 46.8 1.0 C21 B:XZF1102 2.7 46.8 1.0 O11 B:XZF1102 3.0 46.8 1.0 O10 B:XZF1102 3.0 46.8 1.0 S04 B:XZF1102 3.1 46.8 1.0 CE1 B:PHE223 3.6 40.6 1.0 CG B:LEU355 3.6 42.5 1.0 CD1 B:LEU355 3.6 42.5 1.0 CB B:LEU355 3.7 42.5 1.0 CZ B:PHE223 3.8 40.6 1.0 OH B:TYR540 3.8 34.2 1.0 C20 B:XZF1102 4.0 46.8 1.0 C17 B:XZF1102 4.1 46.8 1.0 CE1 B:TYR540 4.2 34.2 1.0 CD1 B:PHE536 4.3 39.5 1.0 N B:LEU355 4.4 42.5 1.0 CZ B:TYR540 4.5 34.2 1.0 CA B:GLY353 4.5 43.4 1.0 C16 B:XZF1102 4.5 46.8 1.0 CE1 B:PHE536 4.5 39.5 1.0 CA B:LEU355 4.6 42.5 1.0 N B:GLY353 4.7 43.4 1.0 CD1 B:PHE223 4.8 40.6 1.0 N14 B:XZF1102 4.8 46.8 1.0 C B:GLY353 4.9 43.4 1.0 N B:ILE354 4.9 41.3 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0