Chlorine in PDB 8fht: Cryo-Em Structure of Human Ncc

The structure of Cryo-Em Structure of Human Ncc also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the Cryo-Em Structure of Human Ncc (pdb code 8fht). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Cryo-Em Structure of Human Ncc, PDB code: 8fht:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cryo-Em Structure of Human Ncc within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1102 b:43.3 occ:1.00 OH A:TYR540 2.7 33.6 1.0 N A:GLY353 3.1 30.2 1.0 N A:ILE354 3.3 34.3 1.0 CD2 A:LEU355 3.4 42.7 1.0 CA A:GLY353 3.5 30.2 1.0 N A:LEU355 3.7 42.7 1.0 CE1 A:PHE536 3.7 31.9 1.0 C A:GLY353 3.7 30.2 1.0 CZ A:TYR540 3.8 33.6 1.0 CE1 A:TYR540 4.0 33.6 1.0 CB A:LEU355 4.1 42.7 1.0 CG1 A:ILE354 4.2 34.3 1.0 CE1 A:PHE223 4.2 45.4 1.0 C A:THR352 4.2 26.1 1.0 CG A:LEU355 4.3 42.7 1.0 CD1 A:PHE536 4.3 31.9 1.0 CZ A:PHE536 4.3 31.9 1.0 CA A:ILE354 4.4 34.3 1.0 CB A:THR352 4.4 26.1 1.0 C A:ILE354 4.5 34.3 1.0 CA A:THR352 4.5 26.1 1.0 CA A:LEU355 4.5 42.7 1.0 CZ A:PHE223 4.7 45.4 1.0 O A:GLY353 4.8 30.2 1.0 CB A:ILE354 4.8 34.3 1.0 CE2 A:TYR540 5.0 33.6 1.0

Chlorine binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cryo-Em Structure of Human Ncc within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1102 b:43.8 occ:1.00 OH B:TYR540 2.6 34.1 1.0 N B:GLY353 3.1 30.4 1.0 N B:ILE354 3.3 34.7 1.0 CD2 B:LEU355 3.4 43.3 1.0 CA B:GLY353 3.5 30.4 1.0 N B:LEU355 3.7 43.3 1.0 CZ B:TYR540 3.7 34.1 1.0 C B:GLY353 3.7 30.4 1.0 CE1 B:PHE536 3.8 32.5 1.0 CE1 B:TYR540 4.0 34.1 1.0 CD1 B:PHE536 4.0 32.5 1.0 CB B:LEU355 4.1 43.3 1.0 CG1 B:ILE354 4.2 34.7 1.0 C B:THR352 4.2 26.7 1.0 CE1 B:PHE223 4.2 46.0 1.0 CG B:LEU355 4.2 43.3 1.0 CA B:ILE354 4.4 34.7 1.0 CB B:THR352 4.4 26.7 1.0 CA B:THR352 4.5 26.7 1.0 C B:ILE354 4.5 34.7 1.0 CA B:LEU355 4.5 43.3 1.0 CZ B:PHE223 4.7 46.0 1.0 O B:GLY353 4.8 30.4 1.0 CZ B:PHE536 4.8 32.5 1.0 CB B:ILE354 4.8 34.7 1.0 CE2 B:TYR540 4.9 34.1 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0