Chlorine in PDB 8fp4: GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610)

The binding sites of Chlorine atom in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610) (pdb code 8fp4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610), PDB code: 8fp4:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610) within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl401 b:73.4 occ:1.00 N F:TRP64 3.0 47.6 1.0 N F:ARG65 3.1 57.6 1.0 O F:HOH502 3.2 41.6 1.0 CD1 F:TRP64 3.3 47.8 1.0 NH2 F:ARG65 3.4 62.0 1.0 CZ F:ARG65 3.4 64.9 1.0 CB F:ASP31 3.4 56.5 1.0 NH1 F:ARG65 3.5 62.5 1.0 N F:LEU63 3.5 36.3 1.0 CB F:TRP64 3.5 48.9 1.0 CA F:TRP64 3.6 50.0 1.0 CG F:TRP64 3.7 49.2 1.0 O F:THR30 3.8 45.8 1.0 C F:TRP64 3.8 50.6 1.0 CA F:ASP31 3.8 54.8 1.0 CA F:GLY62 3.9 29.2 1.0 C F:GLY62 3.9 31.4 1.0 NE F:ARG65 4.0 62.9 1.0 O F:ARG65 4.0 58.7 1.0 C F:LEU63 4.0 39.7 1.0 CA F:ARG65 4.1 58.8 1.0 CB F:ARG65 4.2 58.6 1.0 C F:THR30 4.3 43.7 1.0 CA F:LEU63 4.3 39.1 1.0 N F:GLY62 4.3 33.7 1.0 O F:GLY29 4.3 42.6 1.0 OD2 F:ASP31 4.3 57.6 1.0 CG F:ARG65 4.3 59.8 1.0 N F:ASP31 4.3 53.8 1.0 CG F:ASP31 4.4 58.3 1.0 NE1 F:TRP64 4.4 45.2 1.0 C F:ARG65 4.6 58.6 1.0 CD F:ARG65 4.8 59.5 1.0 CB F:LEU63 4.8 38.5 1.0 O F:GLY62 4.8 39.9 1.0 O F:VAL28 5.0 37.4 1.0

Chlorine binding site 2 out of 2 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open- NA610) within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl401 b:72.6 occ:1.00 N H:TRP64 3.0 48.9 1.0 N H:ARG65 3.1 59.1 1.0 O H:HOH502 3.2 42.5 1.0 CD1 H:TRP64 3.3 49.4 1.0 NH2 H:ARG65 3.4 63.4 1.0 CZ H:ARG65 3.4 66.0 1.0 CB H:ASP31 3.4 57.4 1.0 NH1 H:ARG65 3.5 63.5 1.0 N H:LEU63 3.5 36.2 1.0 CB H:TRP64 3.5 50.6 1.0 CA H:TRP64 3.6 51.6 1.0 CG H:TRP64 3.7 50.8 1.0 O H:THR30 3.8 45.7 1.0 C H:TRP64 3.8 52.0 1.0 CA H:ASP31 3.8 55.1 1.0 CA H:GLY62 3.9 28.8 1.0 C H:GLY62 3.9 31.2 1.0 O H:ARG65 4.0 60.2 1.0 NE H:ARG65 4.0 64.2 1.0 C H:LEU63 4.0 39.2 1.0 CA H:ARG65 4.1 60.3 1.0 CB H:ARG65 4.2 60.1 1.0 C H:THR30 4.3 43.2 1.0 CA H:LEU63 4.3 39.1 1.0 N H:GLY62 4.3 33.3 1.0 O H:GLY29 4.3 42.7 1.0 OD2 H:ASP31 4.3 57.9 1.0 CG H:ARG65 4.3 61.4 1.0 N H:ASP31 4.3 54.1 1.0 CG H:ASP31 4.4 58.5 1.0 NE1 H:TRP64 4.4 46.4 1.0 C H:ARG65 4.6 59.9 1.0 CD H:ARG65 4.8 61.1 1.0 CB H:LEU63 4.8 38.4 1.0 O H:GLY62 4.8 39.6 1.0 O H:VAL28 5.0 36.8 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3