Chlorine in PDB 8fp9: GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg)

Other elements in 8fp9:

The structure of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg) also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg) (pdb code 8fp9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg), PDB code: 8fp9:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 8fp9

Go back to Chlorine Binding Sites List in 8fp9
Chlorine binding site 1 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg) within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl401

b:67.4
occ:1.00
 N E:TRP64 2.6 37.3 1.0
N E:LEU63 2.7 19.6 1.0
OD1 E:ASP31 2.9 55.1 1.0
CD1 E:TRP64 3.2 41.6 1.0
N E:ARG65 3.4 66.0 1.0
C E:GLY62 3.4 12.5 1.0
CA E:GLY62 3.4 28.5 1.0
CA E:TRP64 3.5 38.8 1.0
C E:LEU63 3.5 27.5 1.0
CA E:LEU63 3.5 23.0 1.0
CB E:TRP64 3.5 38.5 1.0
CG E:TRP64 3.7 43.3 1.0
O E:THR30 3.7 42.6 1.0
C E:TRP64 3.9 44.2 1.0
O E:ARG65 4.0 71.5 1.0
CG E:ASP31 4.1 56.4 1.0
CB E:LEU63 4.1 13.6 1.0
N E:GLY62 4.2 35.0 1.0
CA E:ASP31 4.3 48.4 1.0
NE1 E:TRP64 4.3 37.6 1.0
CG E:ARG65 4.3 69.8 1.0
C E:THR30 4.4 39.0 1.0
CA E:ARG65 4.5 67.3 1.0
O E:GLY62 4.5 21.3 1.0
CB E:ASP31 4.5 50.9 1.0
O E:HOH511 4.6 51.5 1.0
O E:LEU63 4.7 27.3 1.0
C E:ARG65 4.7 70.0 1.0
O E:VAL28 4.7 49.0 1.0
N E:ASP31 4.8 47.3 1.0
CD E:ARG65 4.9 70.9 1.0
CD2 E:TRP64 4.9 41.9 1.0
CB E:ARG65 4.9 68.6 1.0

Chlorine binding site 2 out of 4 in 8fp9

Go back to Chlorine Binding Sites List in 8fp9
Chlorine binding site 2 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg) within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl401

b:67.6
occ:1.00
 N G:TRP64 2.6 36.6 1.0
N G:LEU63 2.6 19.8 1.0
OD1 G:ASP31 2.9 55.5 1.0
CD1 G:TRP64 3.2 41.4 1.0
C G:GLY62 3.4 13.7 1.0
N G:ARG65 3.4 65.6 1.0
CA G:GLY62 3.4 28.6 1.0
C G:LEU63 3.5 27.0 1.0
CA G:LEU63 3.5 22.8 1.0
CA G:TRP64 3.5 39.1 1.0
CB G:TRP64 3.7 39.0 1.0
CG G:TRP64 3.7 43.1 1.0
O G:THR30 3.8 43.7 1.0
C G:TRP64 3.9 44.1 1.0
O G:ARG65 4.0 71.0 1.0
CB G:LEU63 4.0 13.9 1.0
CG G:ASP31 4.1 57.0 1.0
N G:GLY62 4.1 35.5 1.0
CG G:ARG65 4.2 69.8 1.0
NE1 G:TRP64 4.3 36.8 1.0
CA G:ASP31 4.3 48.7 1.0
O G:GLY62 4.5 22.2 1.0
C G:THR30 4.5 40.2 1.0
CA G:ARG65 4.5 67.2 1.0
CB G:ASP31 4.6 51.2 1.0
O G:HOH511 4.6 51.9 1.0
O G:LEU63 4.7 26.7 1.0
C G:ARG65 4.7 69.8 1.0
O G:VAL28 4.7 49.3 1.0
N G:ASP31 4.8 47.8 1.0
CD G:ARG65 4.9 70.8 1.0
CB G:ARG65 4.9 68.4 1.0
CD2 G:TRP64 5.0 41.8 1.0

Chlorine binding site 3 out of 4 in 8fp9

Go back to Chlorine Binding Sites List in 8fp9
Chlorine binding site 3 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg) within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl401

b:81.0
occ:1.00
 N F:TRP64 3.0 43.5 1.0
N F:LEU63 3.3 26.3 1.0
CD1 F:TRP64 3.4 47.9 1.0
N F:ARG65 3.4 65.1 1.0
CB F:ASP31 3.4 52.3 1.0
CB F:TRP64 3.5 47.5 1.0
CA F:TRP64 3.7 47.2 1.0
CA F:GLY62 3.8 26.9 1.0
CG F:TRP64 3.8 50.0 1.0
O F:THR30 3.8 55.7 1.0
CG F:ARG65 3.9 65.7 1.0
CA F:ASP31 3.9 49.2 1.0
C F:GLY62 3.9 24.3 1.0
C F:LEU63 4.0 31.6 1.0
C F:TRP64 4.0 51.7 1.0
O F:ARG65 4.1 65.4 1.0
CA F:LEU63 4.2 27.8 1.0
CD F:ARG65 4.2 65.7 1.0
N F:GLY62 4.2 36.4 1.0
C F:THR30 4.3 53.3 1.0
O F:GLY29 4.4 52.6 1.0
OD2 F:ASP31 4.4 57.1 1.0
N F:ASP31 4.4 50.1 1.0
CG F:ASP31 4.4 56.6 1.0
CA F:ARG65 4.5 64.7 1.0
NE1 F:TRP64 4.5 46.8 1.0
CB F:ARG65 4.7 65.7 1.0
CB F:LEU63 4.7 25.1 1.0
C F:ARG65 4.7 64.9 1.0
O F:VAL28 4.9 45.1 1.0

Chlorine binding site 4 out of 4 in 8fp9

Go back to Chlorine Binding Sites List in 8fp9
Chlorine binding site 4 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg) within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl401

b:82.2
occ:1.00
 N H:TRP64 3.0 42.6 1.0
N H:LEU63 3.3 25.7 1.0
N H:ARG65 3.4 65.4 1.0
CD1 H:TRP64 3.4 46.6 1.0
CB H:ASP31 3.4 53.2 1.0
CB H:TRP64 3.5 46.5 1.0
CA H:TRP64 3.7 46.2 1.0
CA H:GLY62 3.8 27.6 1.0
CG H:TRP64 3.8 49.1 1.0
CG H:ARG65 3.8 66.4 1.0
O H:THR30 3.8 54.8 1.0
CA H:ASP31 3.9 50.0 1.0
C H:GLY62 3.9 24.9 1.0
C H:LEU63 4.0 31.2 1.0
C H:TRP64 4.0 51.0 1.0
O H:ARG65 4.1 66.3 1.0
CA H:LEU63 4.2 27.7 1.0
N H:GLY62 4.2 36.6 1.0
CD H:ARG65 4.3 67.1 1.0
C H:THR30 4.3 52.5 1.0
O H:GLY29 4.4 52.1 1.0
N H:ASP31 4.4 50.7 1.0
OD2 H:ASP31 4.4 57.9 1.0
CG H:ASP31 4.4 57.2 1.0
CA H:ARG65 4.5 65.2 1.0
NE1 H:TRP64 4.6 45.4 1.0
CB H:ARG65 4.7 66.4 1.0
CB H:LEU63 4.7 24.7 1.0
C H:ARG65 4.8 65.5 1.0
O H:VAL28 4.9 45.9 1.0

Reference:

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3
Page generated: Tue Jul 30 09:39:59 2024

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