Chlorine in PDB 8fpg: GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)

The binding sites of Chlorine atom in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) (pdb code 8fpg). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg), PDB code: 8fpg:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl401 b:65.2 occ:1.00 N H:TRP64 2.5 47.8 1.0 N H:LEU63 2.7 35.3 1.0 O H:HOH504 2.7 45.3 1.0 OD1 H:ASP31 3.0 53.8 1.0 CD1 H:TRP64 3.2 45.3 1.0 N H:ARG65 3.3 54.7 1.0 C H:GLY62 3.4 26.8 1.0 CA H:TRP64 3.4 49.1 1.0 C H:LEU63 3.4 36.9 1.0 CA H:GLY62 3.4 25.5 1.0 CA H:LEU63 3.5 37.5 1.0 CB H:TRP64 3.6 48.8 1.0 CG H:TRP64 3.7 49.4 1.0 C H:TRP64 3.8 47.4 1.0 O H:ARG65 3.9 59.9 1.0 O H:THR30 4.0 44.4 1.0 N H:GLY62 4.0 30.7 1.0 CG H:ASP31 4.1 54.6 1.0 CB H:LEU63 4.2 37.4 1.0 NE1 H:TRP64 4.3 44.3 1.0 CG H:ARG65 4.4 54.5 1.0 CA H:ARG65 4.4 55.0 1.0 O H:GLY62 4.5 32.9 1.0 CA H:ASP31 4.6 49.0 1.0 C H:ARG65 4.6 54.5 1.0 O H:LEU63 4.6 39.0 1.0 CB H:ASP31 4.7 50.1 1.0 C H:THR30 4.8 44.4 1.0 CD H:ARG65 4.8 57.8 1.0 CB H:ARG65 4.9 57.5 1.0 CD2 H:TRP64 4.9 48.4 1.0

Chlorine binding site 2 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ F:Cl401 b:67.8 occ:1.00 N F:TRP64 2.5 47.7 1.0 N F:LEU63 2.6 36.9 1.0 O F:HOH504 2.7 45.7 1.0 OD1 F:ASP31 3.0 54.6 1.0 CD1 F:TRP64 3.2 45.9 1.0 N F:ARG65 3.3 55.2 1.0 C F:GLY62 3.4 27.8 1.0 CA F:TRP64 3.4 49.2 1.0 C F:LEU63 3.4 38.0 1.0 CA F:GLY62 3.4 27.3 1.0 CA F:LEU63 3.5 38.8 1.0 CB F:TRP64 3.6 49.9 1.0 CG F:TRP64 3.7 50.4 1.0 C F:TRP64 3.8 48.5 1.0 O F:ARG65 3.9 60.6 1.0 O F:THR30 4.0 43.9 1.0 N F:GLY62 4.0 31.9 1.0 CG F:ASP31 4.1 55.4 1.0 CB F:LEU63 4.2 38.2 1.0 NE1 F:TRP64 4.3 45.5 1.0 CG F:ARG65 4.3 55.7 1.0 CA F:ARG65 4.4 55.9 1.0 O F:GLY62 4.5 32.8 1.0 CA F:ASP31 4.6 49.5 1.0 C F:ARG65 4.6 56.3 1.0 O F:LEU63 4.6 40.5 1.0 CB F:ASP31 4.6 51.0 1.0 C F:THR30 4.8 42.7 1.0 CB F:ARG65 4.9 58.5 1.0 CD F:ARG65 4.9 58.1 1.0 NE F:ARG65 4.9 60.1 1.0 CD2 F:TRP64 5.0 49.2 1.0

Chlorine binding site 3 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl401 b:78.0 occ:1.00 N E:TRP64 3.3 47.9 1.0 CD1 E:TRP64 3.3 48.4 1.0 N E:ARG65 3.3 59.0 1.0 CB E:TRP64 3.4 47.1 1.0 CB E:ASP31 3.5 55.8 1.0 CG E:TRP64 3.7 50.8 1.0 CA E:TRP64 3.7 47.0 1.0 CG E:ARG65 3.7 61.2 1.0 CA E:ASP31 3.9 56.4 1.0 C E:TRP64 3.9 51.6 1.0 N E:LEU63 4.0 34.0 1.0 O E:ARG65 4.1 64.1 1.0 N E:ASP31 4.2 54.2 1.0 CD E:ARG65 4.2 60.9 1.0 OD2 E:ASP31 4.2 62.1 1.0 CG E:ASP31 4.2 59.5 1.0 CA E:ARG65 4.3 59.1 1.0 C E:THR30 4.4 50.0 1.0 C E:LEU63 4.4 43.0 1.0 O E:THR30 4.4 51.2 1.0 CB E:ARG65 4.4 60.9 1.0 CA E:GLY62 4.4 37.9 1.0 NE1 E:TRP64 4.5 46.2 1.0 C E:GLY62 4.5 32.1 1.0 C E:ARG65 4.6 61.6 1.0 CA E:LEU63 4.7 38.5 1.0 O E:VAL28 4.8 50.5 1.0 N E:GLY62 5.0 37.9 1.0

Chlorine binding site 4 out of 4 in the GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ G:Cl401 b:74.7 occ:1.00 CD1 G:TRP64 3.3 48.0 1.0 N G:TRP64 3.3 47.3 1.0 N G:ARG65 3.3 57.7 1.0 CB G:TRP64 3.4 46.5 1.0 CB G:ASP31 3.5 55.9 1.0 CG G:TRP64 3.7 50.0 1.0 CA G:TRP64 3.7 47.0 1.0 CG G:ARG65 3.7 60.0 1.0 CA G:ASP31 3.9 56.0 1.0 C G:TRP64 3.9 51.3 1.0 N G:LEU63 4.0 34.5 1.0 O G:ARG65 4.1 63.9 1.0 N G:ASP31 4.1 54.4 1.0 CD G:ARG65 4.2 59.6 1.0 OD2 G:ASP31 4.2 61.8 1.0 CG G:ASP31 4.2 59.2 1.0 CA G:ARG65 4.3 58.0 1.0 C G:THR30 4.4 50.6 1.0 C G:LEU63 4.4 43.4 1.0 O G:THR30 4.4 51.8 1.0 CB G:ARG65 4.4 59.3 1.0 CA G:GLY62 4.4 38.0 1.0 NE1 G:TRP64 4.5 45.5 1.0 C G:GLY62 4.5 32.6 1.0 C G:ARG65 4.7 61.8 1.0 CA G:LEU63 4.7 38.4 1.0 O G:VAL28 4.9 50.3 1.0 N G:GLY62 5.0 37.5 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3