Chlorine in PDB 8fpl: Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)

The binding sites of Chlorine atom in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) (pdb code 8fpl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg), PDB code: 8fpl:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl902 b:83.8 occ:1.00 CL B:CYZ902 0.0 83.8 1.0 C13 B:CYZ902 1.8 76.2 1.0 C12 B:CYZ902 2.8 77.5 1.0 C14 B:CYZ902 2.8 76.0 1.0 O4 B:CYZ902 3.1 75.3 1.0 OD1 B:ASP760 3.1 63.6 1.0 S2 B:CYZ902 3.2 84.2 1.0 N B:ASP760 3.3 51.0 1.0 CG B:ASP760 3.3 60.5 1.0 CB B:LEU759 3.4 30.7 1.0 N3 B:CYZ902 3.4 77.4 1.0 C B:LEU759 3.6 32.8 1.0 OD2 B:ASP760 3.7 61.7 1.0 CA B:ASP760 3.7 48.6 1.0 C11 B:CYZ902 4.0 74.8 1.0 O B:LEU759 4.0 37.3 1.0 CB B:ASP760 4.1 51.8 1.0 C10 B:CYZ902 4.1 77.3 1.0 CA B:LEU759 4.1 29.0 1.0 O B:PHE495 4.6 46.9 1.0 C9 B:CYZ902 4.6 75.5 1.0 CG B:LEU759 4.7 30.2 1.0 CD1 B:LEU759 4.7 28.6 1.0 O3 B:CYZ902 4.8 76.5 1.0 N B:LEU759 4.9 34.9 1.0 CB C:SER729 5.0 49.7 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:74.7 occ:1.00 CL C:CYZ902 0.0 74.7 1.0 C13 C:CYZ902 1.8 62.4 1.0 C12 C:CYZ902 2.7 63.3 1.0 C14 C:CYZ902 2.8 58.5 1.0 OD1 C:ASP760 2.9 48.0 1.0 O4 C:CYZ902 3.0 64.2 1.0 S2 C:CYZ902 3.2 73.8 1.0 CB C:LEU759 3.3 26.5 1.0 N C:ASP760 3.4 31.4 1.0 N3 C:CYZ902 3.4 66.8 1.0 C C:LEU759 3.5 26.7 1.0 CG C:ASP760 3.7 46.5 1.0 CA C:ASP760 3.8 32.6 1.0 O C:LEU759 4.0 34.0 1.0 C11 C:CYZ902 4.0 60.6 1.0 CA C:LEU759 4.0 22.8 1.0 C10 C:CYZ902 4.1 60.6 1.0 CB C:ASP760 4.3 40.4 1.0 O C:PHE495 4.4 44.5 1.0 CD1 C:LEU759 4.6 16.9 1.0 CG C:LEU759 4.6 22.3 1.0 C9 C:CYZ902 4.6 61.0 1.0 OD2 C:ASP760 4.6 44.9 1.0 O3 C:CYZ902 4.8 62.1 1.0 N C:LEU759 4.9 23.1 1.0 OG C:SER754 4.9 26.2 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:74.5 occ:1.00 CL A:CYZ902 0.0 74.5 1.0 C13 A:CYZ902 1.8 60.6 1.0 C12 A:CYZ902 2.7 61.4 1.0 C14 A:CYZ902 2.8 57.9 1.0 OD2 A:ASP760 2.9 49.6 1.0 O4 A:CYZ902 3.0 63.9 1.0 S2 A:CYZ902 3.1 71.7 1.0 CB A:LEU759 3.3 30.0 1.0 N3 A:CYZ902 3.4 63.9 1.0 N A:ASP760 3.5 32.5 1.0 C A:LEU759 3.5 28.6 1.0 O A:LEU759 3.9 35.0 1.0 CG A:ASP760 3.9 47.5 1.0 CA A:ASP760 4.0 32.3 1.0 C11 A:CYZ902 4.0 58.6 1.0 CA A:LEU759 4.0 25.0 1.0 C10 A:CYZ902 4.1 59.0 1.0 O A:PHE495 4.3 42.7 1.0 CB A:ASP760 4.5 41.7 1.0 CD1 A:LEU759 4.5 19.5 1.0 CG A:LEU759 4.5 25.1 1.0 C9 A:CYZ902 4.6 58.9 1.0 O3 A:CYZ902 4.8 60.4 1.0 OD1 A:ASP760 4.8 45.6 1.0 N A:LEU759 5.0 24.2 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100UM Cnqx (Closed-Canamg) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl902 b:84.9 occ:1.00 CL D:CYZ902 0.0 84.9 1.0 C13 D:CYZ902 1.8 78.5 1.0 O3 D:CYZ902 2.6 80.1 1.0 C12 D:CYZ902 2.8 79.4 1.0 C14 D:CYZ902 2.8 77.9 1.0 OD1 D:ASP760 3.1 61.0 1.0 S2 D:CYZ902 3.2 85.0 1.0 CG D:ASP760 3.3 58.5 1.0 N D:ASP760 3.3 48.4 1.0 CB D:LEU759 3.4 31.4 1.0 OD2 D:ASP760 3.5 60.0 1.0 C D:LEU759 3.6 32.0 1.0 CA D:ASP760 3.8 46.3 1.0 N3 D:CYZ902 4.0 78.1 1.0 C11 D:CYZ902 4.0 77.2 1.0 CB D:ASP760 4.1 50.6 1.0 C10 D:CYZ902 4.1 78.4 1.0 CA D:LEU759 4.1 28.2 1.0 O D:LEU759 4.1 36.1 1.0 C9 D:CYZ902 4.6 77.2 1.0 O4 D:CYZ902 4.6 79.8 1.0 CG D:LEU759 4.7 30.4 1.0 CD1 D:LEU759 4.7 29.7 1.0 N D:LEU759 4.8 32.3 1.0 O D:PHE495 4.8 47.4 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3