Chlorine in PDB 8fps: GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)
Chlorine Binding Sites:
The binding sites of Chlorine atom in the GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)
(pdb code 8fps). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the
GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K), PDB code: 8fps:
Jump to Chlorine binding site number:
1;
2;
3;
4;
Chlorine binding site 1 out
of 4 in 8fps
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Chlorine Binding Sites List in 8fps
Chlorine binding site 1 out
of 4 in the GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Cl401
b:76.1
occ:1.00
|
N
|
E:TRP64
|
2.9
|
47.4
|
1.0
|
N
|
E:ARG65
|
3.1
|
60.2
|
1.0
|
CD1
|
E:TRP64
|
3.2
|
47.1
|
1.0
|
CB
|
E:ASP31
|
3.4
|
54.8
|
1.0
|
N
|
E:LEU63
|
3.4
|
35.6
|
1.0
|
CB
|
E:TRP64
|
3.5
|
47.0
|
1.0
|
CA
|
E:TRP64
|
3.5
|
48.5
|
1.0
|
CG
|
E:TRP64
|
3.7
|
50.4
|
1.0
|
C
|
E:TRP64
|
3.8
|
50.7
|
1.0
|
CA
|
E:ASP31
|
3.8
|
55.5
|
1.0
|
CA
|
E:GLY62
|
3.8
|
37.3
|
1.0
|
C
|
E:GLY62
|
3.8
|
34.1
|
1.0
|
O
|
E:THR30
|
3.9
|
47.0
|
1.0
|
C
|
E:LEU63
|
3.9
|
38.7
|
1.0
|
CA
|
E:ARG65
|
4.1
|
60.7
|
1.0
|
CB
|
E:ARG65
|
4.1
|
62.3
|
1.0
|
CA
|
E:LEU63
|
4.1
|
38.9
|
1.0
|
O
|
E:ARG65
|
4.2
|
65.6
|
1.0
|
CG
|
E:ARG65
|
4.2
|
64.4
|
1.0
|
C
|
E:THR30
|
4.3
|
43.6
|
1.0
|
N
|
E:GLY62
|
4.3
|
40.4
|
1.0
|
NE1
|
E:TRP64
|
4.4
|
46.6
|
1.0
|
N
|
E:ASP31
|
4.4
|
52.4
|
1.0
|
O
|
E:GLY29
|
4.4
|
42.9
|
1.0
|
CG
|
E:ASP31
|
4.4
|
56.8
|
1.0
|
OD2
|
E:ASP31
|
4.6
|
56.6
|
1.0
|
CB
|
E:LEU63
|
4.6
|
37.6
|
1.0
|
C
|
E:ARG65
|
4.7
|
63.5
|
1.0
|
O
|
E:GLY62
|
4.7
|
42.5
|
1.0
|
O
|
E:TRP64
|
5.0
|
53.3
|
1.0
|
CD2
|
E:TRP64
|
5.0
|
49.1
|
1.0
|
|
Chlorine binding site 2 out
of 4 in 8fps
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Chlorine Binding Sites List in 8fps
Chlorine binding site 2 out
of 4 in the GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Cl401
b:76.2
occ:1.00
|
N
|
G:TRP64
|
2.9
|
47.6
|
1.0
|
N
|
G:ARG65
|
3.1
|
59.2
|
1.0
|
CD1
|
G:TRP64
|
3.2
|
47.5
|
1.0
|
CB
|
G:ASP31
|
3.4
|
55.4
|
1.0
|
N
|
G:LEU63
|
3.4
|
35.4
|
1.0
|
CA
|
G:TRP64
|
3.5
|
48.4
|
1.0
|
CB
|
G:TRP64
|
3.5
|
46.9
|
1.0
|
CG
|
G:TRP64
|
3.7
|
50.1
|
1.0
|
C
|
G:TRP64
|
3.7
|
50.5
|
1.0
|
CA
|
G:GLY62
|
3.8
|
36.6
|
1.0
|
CA
|
G:ASP31
|
3.8
|
56.6
|
1.0
|
C
|
G:GLY62
|
3.8
|
34.4
|
1.0
|
O
|
G:THR30
|
3.9
|
48.8
|
1.0
|
C
|
G:LEU63
|
3.9
|
38.8
|
1.0
|
CA
|
G:ARG65
|
4.1
|
59.6
|
1.0
|
CB
|
G:ARG65
|
4.1
|
61.0
|
1.0
|
CA
|
G:LEU63
|
4.1
|
38.4
|
1.0
|
O
|
G:ARG65
|
4.2
|
65.9
|
1.0
|
CG
|
G:ARG65
|
4.2
|
63.5
|
1.0
|
C
|
G:THR30
|
4.3
|
44.1
|
1.0
|
N
|
G:GLY62
|
4.4
|
39.0
|
1.0
|
O
|
G:GLY29
|
4.4
|
43.4
|
1.0
|
NE1
|
G:TRP64
|
4.4
|
46.5
|
1.0
|
N
|
G:ASP31
|
4.4
|
53.1
|
1.0
|
CG
|
G:ASP31
|
4.4
|
57.5
|
1.0
|
OD2
|
G:ASP31
|
4.6
|
57.9
|
1.0
|
CB
|
G:LEU63
|
4.6
|
38.2
|
1.0
|
C
|
G:ARG65
|
4.6
|
63.1
|
1.0
|
O
|
G:GLY62
|
4.7
|
42.7
|
1.0
|
O
|
G:TRP64
|
5.0
|
53.5
|
1.0
|
|
Chlorine binding site 3 out
of 4 in 8fps
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Chlorine Binding Sites List in 8fps
Chlorine binding site 3 out
of 4 in the GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Cl401
b:81.4
occ:1.00
|
N
|
F:TRP64
|
2.8
|
46.9
|
1.0
|
N
|
F:ARG65
|
3.0
|
52.2
|
1.0
|
N
|
F:LEU63
|
3.2
|
34.7
|
1.0
|
CB
|
F:ASP31
|
3.4
|
54.6
|
1.0
|
O
|
F:HOH501
|
3.5
|
36.4
|
1.0
|
CA
|
F:TRP64
|
3.5
|
47.0
|
1.0
|
CD1
|
F:TRP64
|
3.5
|
46.9
|
1.0
|
CA
|
F:GLY62
|
3.6
|
37.6
|
1.0
|
CG
|
F:ARG65
|
3.6
|
54.9
|
1.0
|
O
|
F:ARG65
|
3.6
|
53.1
|
1.0
|
C
|
F:GLY62
|
3.7
|
35.6
|
1.0
|
CB
|
F:TRP64
|
3.7
|
47.3
|
1.0
|
C
|
F:TRP64
|
3.7
|
47.9
|
1.0
|
C
|
F:LEU63
|
3.8
|
40.5
|
1.0
|
CA
|
F:ASP31
|
3.9
|
52.7
|
1.0
|
N
|
F:GLY62
|
3.9
|
42.2
|
1.0
|
CG
|
F:TRP64
|
3.9
|
47.5
|
1.0
|
CA
|
F:ARG65
|
4.0
|
54.4
|
1.0
|
CA
|
F:LEU63
|
4.0
|
36.8
|
1.0
|
O
|
F:THR30
|
4.1
|
49.1
|
1.0
|
NH1
|
F:ARG65
|
4.1
|
58.2
|
1.0
|
C
|
F:ARG65
|
4.3
|
54.2
|
1.0
|
CB
|
F:ARG65
|
4.3
|
55.9
|
1.0
|
CZ
|
F:ARG65
|
4.5
|
59.7
|
1.0
|
CD
|
F:ARG65
|
4.5
|
54.0
|
1.0
|
CG
|
F:ASP31
|
4.5
|
58.3
|
1.0
|
N
|
F:ASP31
|
4.6
|
54.0
|
1.0
|
C
|
F:THR30
|
4.6
|
48.4
|
1.0
|
NE
|
F:ARG65
|
4.6
|
56.8
|
1.0
|
NE1
|
F:TRP64
|
4.7
|
45.0
|
1.0
|
O
|
F:GLY62
|
4.7
|
44.1
|
1.0
|
OD2
|
F:ASP31
|
4.7
|
58.4
|
1.0
|
CB
|
F:LEU63
|
4.7
|
37.5
|
1.0
|
O
|
F:TRP64
|
4.9
|
53.3
|
1.0
|
O
|
F:GLY29
|
5.0
|
40.1
|
1.0
|
O
|
F:LEU63
|
5.0
|
42.9
|
1.0
|
|
Chlorine binding site 4 out
of 4 in 8fps
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Chlorine Binding Sites List in 8fps
Chlorine binding site 4 out
of 4 in the GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Cl401
b:80.4
occ:1.00
|
N
|
H:TRP64
|
2.8
|
48.6
|
1.0
|
N
|
H:ARG65
|
3.0
|
52.6
|
1.0
|
N
|
H:LEU63
|
3.2
|
36.4
|
1.0
|
CB
|
H:ASP31
|
3.4
|
53.9
|
1.0
|
O
|
H:HOH501
|
3.5
|
36.2
|
1.0
|
CA
|
H:TRP64
|
3.5
|
49.4
|
1.0
|
CD1
|
H:TRP64
|
3.5
|
48.5
|
1.0
|
CA
|
H:GLY62
|
3.6
|
38.1
|
1.0
|
CG
|
H:ARG65
|
3.6
|
55.1
|
1.0
|
O
|
H:ARG65
|
3.7
|
53.0
|
1.0
|
C
|
H:GLY62
|
3.7
|
36.6
|
1.0
|
CB
|
H:TRP64
|
3.7
|
49.3
|
1.0
|
C
|
H:TRP64
|
3.7
|
49.5
|
1.0
|
C
|
H:LEU63
|
3.8
|
41.9
|
1.0
|
CA
|
H:ASP31
|
3.9
|
52.4
|
1.0
|
N
|
H:GLY62
|
3.9
|
42.1
|
1.0
|
CG
|
H:TRP64
|
3.9
|
49.4
|
1.0
|
CA
|
H:ARG65
|
4.0
|
54.6
|
1.0
|
CA
|
H:LEU63
|
4.0
|
38.1
|
1.0
|
O
|
H:THR30
|
4.0
|
49.0
|
1.0
|
NH1
|
H:ARG65
|
4.1
|
58.5
|
1.0
|
C
|
H:ARG65
|
4.3
|
54.1
|
1.0
|
CB
|
H:ARG65
|
4.3
|
55.9
|
1.0
|
CZ
|
H:ARG65
|
4.5
|
60.5
|
1.0
|
CD
|
H:ARG65
|
4.5
|
54.0
|
1.0
|
CG
|
H:ASP31
|
4.5
|
57.9
|
1.0
|
N
|
H:ASP31
|
4.6
|
53.9
|
1.0
|
C
|
H:THR30
|
4.6
|
47.5
|
1.0
|
NE
|
H:ARG65
|
4.6
|
57.0
|
1.0
|
NE1
|
H:TRP64
|
4.7
|
46.2
|
1.0
|
O
|
H:GLY62
|
4.7
|
44.9
|
1.0
|
OD2
|
H:ASP31
|
4.7
|
58.2
|
1.0
|
CB
|
H:LEU63
|
4.7
|
38.2
|
1.0
|
O
|
H:TRP64
|
4.9
|
54.1
|
1.0
|
O
|
H:GLY29
|
4.9
|
39.6
|
1.0
|
O
|
H:LEU63
|
5.0
|
43.4
|
1.0
|
|
Reference:
T.Nakagawa,
X.Wang,
F.J.Miguez-Cabello,
D.Bowie.
The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3
Page generated: Tue Jul 30 09:40:47 2024
|