Chlorine in PDB 8fpv: Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)

The binding sites of Chlorine atom in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) (pdb code 8fpv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610), PDB code: 8fpv:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:69.8 occ:1.00 CL A:CYZ1302 0.0 69.8 1.0 C13 A:CYZ1302 1.8 38.4 1.0 C12 A:CYZ1302 2.7 34.4 1.0 C14 A:CYZ1302 2.8 34.8 1.0 O4 A:CYZ1302 2.9 45.8 1.0 OD1 A:ASP760 3.0 48.4 1.0 S2 A:CYZ1302 3.2 39.7 1.0 N A:ASP760 3.3 22.7 1.0 CB A:LEU759 3.3 25.9 1.0 CG A:ASP760 3.4 44.3 1.0 N3 A:CYZ1302 3.5 44.0 1.0 C A:LEU759 3.6 33.3 1.0 O A:HOH1401 3.6 5.4 1.0 CA A:ASP760 3.7 25.5 1.0 OD2 A:ASP760 3.9 36.5 1.0 C11 A:CYZ1302 4.0 35.0 1.0 O A:LEU759 4.1 37.5 1.0 CA A:LEU759 4.1 28.0 1.0 C10 A:CYZ1302 4.1 29.6 1.0 CB A:ASP760 4.1 35.0 1.0 CG A:LEU759 4.5 26.8 1.0 CD1 A:LEU759 4.6 25.5 1.0 C9 A:CYZ1302 4.6 28.6 1.0 O A:PHE495 4.6 25.3 1.0 O3 A:CYZ1302 4.7 38.0 1.0 CB D:SER729 4.8 26.3 1.0 N A:LEU759 4.9 29.7 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:68.1 occ:1.00 CL B:CYZ1302 0.0 68.1 1.0 C13 B:CYZ1302 1.8 35.5 1.0 C12 B:CYZ1302 2.7 31.6 1.0 C14 B:CYZ1302 2.8 27.8 1.0 O4 B:CYZ1302 3.0 26.7 1.0 S2 B:CYZ1302 3.2 51.2 1.0 N B:ASP760 3.4 34.0 1.0 N3 B:CYZ1302 3.5 33.9 1.0 CA B:ASP760 3.6 37.7 1.0 CB B:LEU759 3.6 29.8 1.0 C B:LEU759 3.7 32.2 1.0 CB B:ASP760 3.9 40.5 1.0 C11 B:CYZ1302 4.0 28.7 1.0 O B:LEU759 4.1 41.5 1.0 C10 B:CYZ1302 4.1 24.2 1.0 O B:HOH1401 4.2 33.5 1.0 CA B:LEU759 4.3 29.9 1.0 CG B:ASP760 4.5 47.1 1.0 C9 B:CYZ1302 4.6 27.5 1.0 OG C:SER729 4.6 40.6 1.0 OD1 B:ASP760 4.7 44.8 1.0 O3 B:CYZ1302 4.8 42.9 1.0 O B:PHE495 4.8 36.9 1.0 CG B:LEU759 4.8 32.4 1.0 CD1 B:LEU759 4.8 29.6 1.0 CB C:SER729 4.9 29.9 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:65.8 occ:1.00 CL C:CYZ1302 0.0 65.8 1.0 C13 C:CYZ1302 1.8 26.3 1.0 C12 C:CYZ1302 2.7 21.7 1.0 C14 C:CYZ1302 2.8 24.2 1.0 O4 C:CYZ1302 2.9 37.9 1.0 N C:ASP760 3.1 20.1 1.0 S2 C:CYZ1302 3.2 37.0 1.0 CB C:LEU759 3.4 21.8 1.0 CA C:ASP760 3.5 22.8 1.0 N3 C:CYZ1302 3.5 34.8 1.0 C C:LEU759 3.6 33.0 1.0 O C:HOH1401 3.7 0.0 1.0 CB C:ASP760 3.7 31.9 1.0 C11 C:CYZ1302 4.0 22.8 1.0 C10 C:CYZ1302 4.1 22.0 1.0 CA C:LEU759 4.1 25.5 1.0 O C:LEU759 4.1 40.2 1.0 OD1 C:ASP760 4.2 39.8 1.0 CG C:ASP760 4.4 40.8 1.0 C9 C:CYZ1302 4.6 19.2 1.0 CG C:LEU759 4.7 25.2 1.0 O3 C:CYZ1302 4.8 26.8 1.0 CD1 C:LEU759 4.8 24.9 1.0 N C:LEU759 4.9 29.3 1.0 CB B:SER729 4.9 20.6 1.0 O C:PHE495 4.9 26.4 1.0 C C:ASP760 5.0 29.2 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 1 (LBDCONF1) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1302 b:69.4 occ:1.00 CL D:CYZ1302 0.0 69.4 1.0 C13 D:CYZ1302 1.8 36.8 1.0 C12 D:CYZ1302 2.7 30.7 1.0 C14 D:CYZ1302 2.8 31.9 1.0 OD2 D:ASP760 2.9 40.6 1.0 O4 D:CYZ1302 3.0 32.8 1.0 S2 D:CYZ1302 3.2 52.6 1.0 CG D:ASP760 3.4 49.2 1.0 N D:ASP760 3.4 30.5 1.0 CB D:LEU759 3.5 31.2 1.0 N3 D:CYZ1302 3.5 38.2 1.0 C D:LEU759 3.6 25.2 1.0 CA D:ASP760 3.7 39.1 1.0 O D:HOH1401 3.8 35.2 1.0 OD1 D:ASP760 3.9 48.8 1.0 O D:LEU759 3.9 34.5 1.0 C11 D:CYZ1302 4.0 29.9 1.0 C10 D:CYZ1302 4.1 27.4 1.0 CB D:ASP760 4.1 42.3 1.0 CA D:LEU759 4.1 27.7 1.0 O D:PHE495 4.3 37.6 1.0 C9 D:CYZ1302 4.6 30.3 1.0 CD1 D:LEU759 4.6 27.9 1.0 OG A:SER729 4.6 44.1 1.0 CG D:LEU759 4.6 26.8 1.0 O3 D:CYZ1302 4.8 47.4 1.0

T.Nakagawa, X.T.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3