Chlorine in PDB 8fpy: Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) (pdb code 8fpy). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610), PDB code: 8fpy:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 8fpy

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Chlorine binding site 1 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1302

b:76.3
occ:1.00
CL A:CYZ1302 0.0 76.3 1.0
C13 A:CYZ1302 1.8 30.1 1.0
C12 A:CYZ1302 2.7 26.5 1.0
C14 A:CYZ1302 2.8 27.1 1.0
O4 A:CYZ1302 2.9 49.1 1.0
S2 A:CYZ1302 3.2 50.6 1.0
N A:ASP760 3.2 37.0 1.0
O A:HOH1401 3.3 25.3 1.0
CB A:LEU759 3.5 30.2 1.0
CA A:ASP760 3.5 40.2 1.0
N3 A:CYZ1302 3.5 40.3 1.0
C A:LEU759 3.6 38.3 1.0
CB A:ASP760 3.8 46.6 1.0
C11 A:CYZ1302 4.0 25.3 1.0
O A:LEU759 4.0 47.0 1.0
C10 A:CYZ1302 4.1 29.7 1.0
CA A:LEU759 4.1 29.1 1.0
C9 A:CYZ1302 4.6 31.5 1.0
O A:PHE495 4.6 39.5 1.0
OD2 A:ASP760 4.7 58.8 1.0
CG A:LEU759 4.7 35.0 1.0
O3 A:CYZ1302 4.8 41.0 1.0
CD1 A:LEU759 4.8 31.7 1.0
CG A:ASP760 4.8 54.4 1.0
N A:LEU759 4.9 34.9 1.0
C A:ASP760 5.0 44.5 1.0

Chlorine binding site 2 out of 4 in 8fpy

Go back to Chlorine Binding Sites List in 8fpy
Chlorine binding site 2 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1302

b:84.0
occ:1.00
CL B:CYZ1302 0.0 84.0 1.0
C13 B:CYZ1302 1.8 43.7 1.0
C12 B:CYZ1302 2.7 43.1 1.0
C14 B:CYZ1302 2.8 38.0 1.0
O4 B:CYZ1302 2.9 37.4 1.0
S2 B:CYZ1302 3.2 55.4 1.0
N B:ASP760 3.3 41.2 1.0
CB B:LEU759 3.6 45.6 1.0
N3 B:CYZ1302 3.6 48.9 1.0
CA B:ASP760 3.6 48.2 1.0
C B:LEU759 3.7 41.9 1.0
CB B:ASP760 3.8 55.8 1.0
O B:HOH1401 3.9 32.5 1.0
OG C:SER729 4.0 46.4 1.0
C11 B:CYZ1302 4.0 41.3 1.0
C10 B:CYZ1302 4.1 38.0 1.0
O B:LEU759 4.2 51.3 1.0
CA B:LEU759 4.3 44.8 1.0
C9 B:CYZ1302 4.6 37.9 1.0
CB C:SER729 4.6 39.5 1.0
O B:PHE495 4.6 47.0 1.0
CD1 B:LEU759 4.8 38.3 1.0
O3 B:CYZ1302 4.8 51.8 1.0
CG B:LEU759 4.8 39.4 1.0
CG B:ASP760 5.0 64.1 1.0

Chlorine binding site 3 out of 4 in 8fpy

Go back to Chlorine Binding Sites List in 8fpy
Chlorine binding site 3 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1302

b:72.5
occ:1.00
CL C:CYZ1302 0.0 72.5 1.0
C13 C:CYZ1302 1.8 27.1 1.0
C12 C:CYZ1302 2.7 28.4 1.0
C14 C:CYZ1302 2.8 25.1 1.0
O4 C:CYZ1302 2.9 50.3 1.0
S2 C:CYZ1302 3.2 54.5 1.0
N C:ASP760 3.2 43.9 1.0
O C:HOH1401 3.3 21.3 1.0
CB C:LEU759 3.5 34.1 1.0
C C:LEU759 3.5 37.7 1.0
CA C:ASP760 3.5 42.7 1.0
N3 C:CYZ1302 3.5 37.5 1.0
CB C:ASP760 3.9 50.0 1.0
O C:LEU759 4.0 39.8 1.0
C11 C:CYZ1302 4.0 26.3 1.0
C10 C:CYZ1302 4.1 29.3 1.0
CA C:LEU759 4.1 25.9 1.0
C9 C:CYZ1302 4.6 29.3 1.0
OD2 C:ASP760 4.6 57.6 1.0
O C:PHE495 4.6 38.4 1.0
CG C:LEU759 4.8 34.4 1.0
O3 C:CYZ1302 4.8 41.6 1.0
CG C:ASP760 4.8 54.8 1.0
CD1 C:LEU759 4.8 28.2 1.0
N C:LEU759 5.0 32.3 1.0
C C:ASP760 5.0 42.4 1.0

Chlorine binding site 4 out of 4 in 8fpy

Go back to Chlorine Binding Sites List in 8fpy
Chlorine binding site 4 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1302

b:86.5
occ:1.00
CL D:CYZ1302 0.0 86.5 1.0
C13 D:CYZ1302 1.8 46.1 1.0
C12 D:CYZ1302 2.7 44.7 1.0
C14 D:CYZ1302 2.8 41.2 1.0
O4 D:CYZ1302 2.9 41.0 1.0
S2 D:CYZ1302 3.2 58.4 1.0
N D:ASP760 3.3 45.0 1.0
CB D:ASP760 3.4 61.0 1.0
CA D:ASP760 3.5 56.4 1.0
N3 D:CYZ1302 3.6 51.1 1.0
CB D:LEU759 3.6 49.7 1.0
C D:LEU759 3.8 45.3 1.0
O D:HOH1401 4.0 39.9 1.0
C11 D:CYZ1302 4.0 42.4 1.0
C10 D:CYZ1302 4.1 40.1 1.0
CA D:LEU759 4.3 49.7 1.0
O D:LEU759 4.4 56.1 1.0
O D:PHE495 4.5 45.4 1.0
C9 D:CYZ1302 4.6 39.8 1.0
OG A:SER729 4.6 46.8 1.0
CG D:ASP760 4.6 66.9 1.0
CB A:SER729 4.7 39.0 1.0
O3 D:CYZ1302 4.8 50.9 1.0
CD1 D:LEU759 4.8 41.0 1.0
CG D:LEU759 4.8 46.5 1.0

Reference:

T.Nakagawa, X.T.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3
Page generated: Tue Jul 30 09:41:34 2024

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