Chlorine in PDB 8fpz: Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)

The binding sites of Chlorine atom in the Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) (pdb code 8fpz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610), PDB code: 8fpz:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:48.6 occ:1.00 CL A:CYZ1302 0.0 48.6 1.0 C13 A:CYZ1302 1.8 18.2 1.0 C12 A:CYZ1302 2.7 19.9 1.0 O4 A:CYZ1302 2.7 40.4 1.0 C14 A:CYZ1302 2.8 13.4 1.0 OD1 A:ASP760 2.9 40.1 1.0 S2 A:CYZ1302 3.1 37.9 1.0 O A:HOH1401 3.3 1.7 1.0 CB A:LEU759 3.5 29.2 1.0 N3 A:CYZ1302 3.6 21.7 1.0 N A:ASP760 3.6 28.8 1.0 CG A:ASP760 3.7 39.6 1.0 C A:LEU759 3.8 29.9 1.0 CA A:ASP760 4.0 27.6 1.0 C11 A:CYZ1302 4.0 16.0 1.0 C10 A:CYZ1302 4.1 15.8 1.0 O A:LEU759 4.1 32.9 1.0 CA A:LEU759 4.3 25.4 1.0 OD2 A:ASP760 4.3 32.0 1.0 O A:PHE495 4.3 17.1 1.0 CB A:ASP760 4.4 26.4 1.0 C9 A:CYZ1302 4.6 15.3 1.0 CD1 A:LEU759 4.7 17.8 1.0 O3 A:CYZ1302 4.7 25.8 1.0 CG A:LEU759 4.7 24.4 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:68.8 occ:1.00 CL B:CYZ1302 0.0 68.8 1.0 C13 B:CYZ1302 1.8 42.8 1.0 C12 B:CYZ1302 2.7 39.0 1.0 C14 B:CYZ1302 2.8 37.3 1.0 O4 B:CYZ1302 2.9 51.0 1.0 OD1 B:ASP760 2.9 54.7 1.0 S2 B:CYZ1302 3.1 56.3 1.0 N3 B:CYZ1302 3.5 37.7 1.0 CB B:LEU759 3.7 36.5 1.0 CG B:ASP760 3.7 56.0 1.0 N B:ASP760 3.8 44.5 1.0 O B:HOH1402 3.9 33.6 1.0 C B:LEU759 4.0 39.4 1.0 C11 B:CYZ1302 4.0 38.9 1.0 CA B:ASP760 4.1 51.4 1.0 C10 B:CYZ1302 4.1 34.5 1.0 O B:LEU759 4.3 44.5 1.0 OD2 B:ASP760 4.4 53.0 1.0 OG C:SER729 4.4 40.1 1.0 O B:PHE495 4.4 39.1 1.0 CA B:LEU759 4.5 39.5 1.0 CB B:ASP760 4.5 51.0 1.0 C9 B:CYZ1302 4.6 37.8 1.0 O3 B:CYZ1302 4.7 44.1 1.0 CD1 B:LEU759 4.8 36.5 1.0 CG B:LEU759 4.9 35.0 1.0 CB C:SER729 4.9 31.2 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:57.0 occ:1.00 CL C:CYZ1302 0.0 57.0 1.0 C13 C:CYZ1302 1.8 21.4 1.0 C12 C:CYZ1302 2.7 21.0 1.0 C14 C:CYZ1302 2.8 14.7 1.0 O4 C:CYZ1302 2.9 39.0 1.0 S2 C:CYZ1302 3.2 44.5 1.0 N C:ASP760 3.3 30.5 1.0 O C:HOH1401 3.3 8.6 1.0 CA C:ASP760 3.5 30.4 1.0 CB C:LEU759 3.6 28.4 1.0 N3 C:CYZ1302 3.6 24.9 1.0 C C:LEU759 3.6 29.5 1.0 CB C:ASP760 3.8 26.9 1.0 C11 C:CYZ1302 4.0 19.9 1.0 O C:LEU759 4.1 32.5 1.0 C10 C:CYZ1302 4.1 16.1 1.0 CA C:LEU759 4.2 26.3 1.0 C9 C:CYZ1302 4.6 20.0 1.0 O C:PHE495 4.6 14.6 1.0 O3 C:CYZ1302 4.8 29.5 1.0 CD1 C:LEU759 4.8 16.5 1.0 CG C:LEU759 4.8 24.4 1.0 CG C:ASP760 5.0 37.2 1.0 C C:ASP760 5.0 33.4 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 3 (LBDCONF3) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 500MM Nacl, 330UM Ctz, and 100MM Glutamate (Open-NA610) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1302 b:69.9 occ:1.00 CL D:CYZ1302 0.0 69.9 1.0 C13 D:CYZ1302 1.8 41.2 1.0 C12 D:CYZ1302 2.8 39.9 1.0 C14 D:CYZ1302 2.8 34.9 1.0 O4 D:CYZ1302 3.0 46.8 1.0 S2 D:CYZ1302 3.2 55.5 1.0 N D:ASP760 3.3 49.9 1.0 CB D:ASP760 3.5 60.0 1.0 N3 D:CYZ1302 3.5 34.9 1.0 CB D:LEU759 3.5 40.7 1.0 CA D:ASP760 3.5 59.1 1.0 C D:LEU759 3.8 39.0 1.0 C11 D:CYZ1302 4.0 39.6 1.0 OG A:SER729 4.0 34.5 1.0 C10 D:CYZ1302 4.1 33.6 1.0 O D:HOH1401 4.1 37.2 1.0 CA D:LEU759 4.3 38.8 1.0 O D:LEU759 4.4 45.5 1.0 C9 D:CYZ1302 4.6 36.4 1.0 CD1 D:LEU759 4.7 41.8 1.0 CG D:LEU759 4.7 39.9 1.0 O3 D:CYZ1302 4.8 46.2 1.0 CG D:ASP760 4.8 62.6 1.0 O D:PHE495 4.9 41.0 1.0

T.Nakagawa, X.T.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3