Chlorine in PDB 8fq3: Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)

The binding sites of Chlorine atom in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) (pdb code 8fq3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K), PDB code: 8fq3:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:57.4 occ:1.00 CL B:CYZ1302 0.0 57.4 1.0 C13 B:CYZ1302 1.8 26.7 1.0 O3 B:CYZ1302 2.6 21.6 1.0 C12 B:CYZ1302 2.7 18.3 1.0 C14 B:CYZ1302 2.8 27.8 1.0 OD1 B:ASP760 3.1 23.1 1.0 OD2 B:ASP760 3.2 31.8 1.0 S2 B:CYZ1302 3.2 22.4 1.0 CG B:ASP760 3.2 33.2 1.0 N B:ASP760 3.7 11.5 1.0 CB B:LEU759 3.9 20.5 1.0 CA B:ASP760 4.0 23.4 1.0 N3 B:CYZ1302 4.0 31.8 1.0 C11 B:CYZ1302 4.0 23.9 1.0 C10 B:CYZ1302 4.1 24.1 1.0 C B:LEU759 4.1 13.9 1.0 CB B:ASP760 4.2 30.8 1.0 OG C:SER729 4.4 34.3 1.0 C9 B:CYZ1302 4.6 27.8 1.0 O4 B:CYZ1302 4.6 24.7 1.0 O B:LEU759 4.6 23.2 1.0 CA B:LEU759 4.6 16.4 1.0 CB C:SER729 4.8 21.1 1.0 O B:PHE495 4.9 22.3 1.0 CD1 B:LEU759 4.9 19.6 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:48.7 occ:1.00 CL C:CYZ1302 0.0 48.7 1.0 C13 C:CYZ1302 1.8 17.6 1.0 C12 C:CYZ1302 2.7 16.0 1.0 C14 C:CYZ1302 2.8 23.7 1.0 O4 C:CYZ1302 2.9 32.0 1.0 O C:HOH1401 3.0 0.0 1.0 S2 C:CYZ1302 3.2 27.8 1.0 N3 C:CYZ1302 3.6 19.0 1.0 N C:ASP760 3.7 26.4 1.0 CB C:LEU759 3.9 33.7 1.0 CA C:ASP760 3.9 28.1 1.0 C C:LEU759 4.0 34.5 1.0 C11 C:CYZ1302 4.0 17.1 1.0 C10 C:CYZ1302 4.1 20.8 1.0 CB C:ASP760 4.1 26.5 1.0 O C:PHE495 4.2 25.7 1.0 O C:LEU759 4.4 42.0 1.0 C9 C:CYZ1302 4.6 18.1 1.0 CA C:LEU759 4.6 30.1 1.0 O3 C:CYZ1302 4.8 27.0 1.0 OD1 C:ASP760 5.0 46.5 1.0 CD1 C:LEU759 5.0 37.7 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1302 b:59.0 occ:1.00 CL D:CYZ1302 0.0 59.0 1.0 C13 D:CYZ1302 1.8 26.2 1.0 O3 D:CYZ1302 2.6 21.7 1.0 C12 D:CYZ1302 2.8 17.9 1.0 C14 D:CYZ1302 2.8 27.8 1.0 OD1 D:ASP760 3.0 20.6 1.0 S2 D:CYZ1302 3.2 22.2 1.0 CG D:ASP760 3.3 31.4 1.0 OD2 D:ASP760 3.5 29.6 1.0 CB D:LEU759 3.6 19.3 1.0 N D:ASP760 3.7 11.4 1.0 C D:LEU759 4.0 11.2 1.0 N3 D:CYZ1302 4.0 30.6 1.0 C11 D:CYZ1302 4.0 23.5 1.0 CA D:ASP760 4.0 24.1 1.0 C10 D:CYZ1302 4.1 23.2 1.0 CB D:ASP760 4.2 30.6 1.0 CA D:LEU759 4.4 13.5 1.0 OG A:SER729 4.5 35.5 1.0 O D:LEU759 4.5 22.6 1.0 C9 D:CYZ1302 4.6 26.6 1.0 O4 D:CYZ1302 4.6 24.5 1.0 CD1 D:LEU759 4.6 18.4 1.0 CG D:LEU759 4.8 19.9 1.0 O D:PHE495 4.8 21.4 1.0 CB A:SER729 4.8 21.8 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform N619K Mutant of Ampa Receptor in Complex with Gain-of-Function Tarp Gamma-2, with 10MM CACL2, 150MM Nacl, 1MM MGCL2, 330UM Ctz, and 100MM Glutamate (Open-Canamg/N619K) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:46.8 occ:1.00 CL A:CYZ1302 0.0 46.8 1.0 C13 A:CYZ1302 1.8 18.1 1.0 C12 A:CYZ1302 2.7 16.3 1.0 C14 A:CYZ1302 2.8 24.4 1.0 O4 A:CYZ1302 2.9 32.9 1.0 O A:HOH1401 2.9 1.7 1.0 S2 A:CYZ1302 3.2 26.8 1.0 N3 A:CYZ1302 3.6 19.7 1.0 N A:ASP760 3.7 25.5 1.0 CB A:LEU759 3.8 32.8 1.0 CA A:ASP760 3.9 27.9 1.0 C A:LEU759 4.0 33.1 1.0 C11 A:CYZ1302 4.0 18.4 1.0 C10 A:CYZ1302 4.1 19.9 1.0 CB A:ASP760 4.1 27.0 1.0 O A:PHE495 4.2 23.1 1.0 O A:LEU759 4.3 41.4 1.0 CA A:LEU759 4.6 29.4 1.0 C9 A:CYZ1302 4.6 17.5 1.0 O3 A:CYZ1302 4.7 25.3 1.0 CD1 A:LEU759 4.9 35.3 1.0 OD1 A:ASP760 5.0 47.6 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3