Chlorine in PDB 8fq6: Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150)

The binding sites of Chlorine atom in the Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150) (pdb code 8fq6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150), PDB code: 8fq6:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:61.4 occ:1.00 CL B:CYZ1302 0.0 61.4 1.0 C13 B:CYZ1302 1.8 39.7 1.0 C12 B:CYZ1302 2.8 39.0 1.0 C14 B:CYZ1302 2.8 33.4 1.0 O4 B:CYZ1302 2.9 39.2 1.0 S2 B:CYZ1302 3.2 41.4 1.0 O B:HOH1401 3.3 24.6 1.0 N B:ASP760 3.4 42.1 1.0 CB B:LEU759 3.5 36.8 1.0 N3 B:CYZ1302 3.6 33.9 1.0 C B:LEU759 3.7 38.8 1.0 CA B:ASP760 3.7 45.8 1.0 C11 B:CYZ1302 4.0 34.8 1.0 OG C:SER729 4.0 31.3 1.0 CB B:ASP760 4.1 47.1 1.0 C10 B:CYZ1302 4.1 31.2 1.0 O B:LEU759 4.2 42.2 1.0 CA B:LEU759 4.2 35.8 1.0 CG B:ASP760 4.5 50.1 1.0 C9 B:CYZ1302 4.6 29.2 1.0 OD1 B:ASP760 4.6 54.0 1.0 CD1 B:LEU759 4.7 33.7 1.0 CG B:LEU759 4.7 34.5 1.0 O B:PHE495 4.7 35.2 1.0 O3 B:CYZ1302 4.8 29.1 1.0

Chlorine binding site 2 out of 4 in the Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:66.2 occ:1.00 CL C:CYZ1302 0.0 66.2 1.0 C13 C:CYZ1302 1.8 30.0 1.0 C12 C:CYZ1302 2.8 24.2 1.0 C14 C:CYZ1302 2.8 22.1 1.0 O4 C:CYZ1302 3.0 29.7 1.0 S2 C:CYZ1302 3.2 43.1 1.0 N C:ASP760 3.2 18.0 1.0 N3 C:CYZ1302 3.5 31.5 1.0 CB C:LEU759 3.6 17.5 1.0 CA C:ASP760 3.6 28.3 1.0 C C:LEU759 3.6 23.6 1.0 O C:HOH1401 3.7 21.5 1.0 CB C:ASP760 3.7 33.1 1.0 C11 C:CYZ1302 4.0 21.3 1.0 C10 C:CYZ1302 4.1 20.9 1.0 CA C:LEU759 4.2 17.8 1.0 O C:LEU759 4.2 38.5 1.0 OD2 C:ASP760 4.3 44.5 1.0 CG C:ASP760 4.4 44.4 1.0 C9 C:CYZ1302 4.6 21.9 1.0 O3 C:CYZ1302 4.8 30.8 1.0 CG C:LEU759 4.8 19.2 1.0 CD1 C:LEU759 4.9 20.7 1.0 O C:PHE495 4.9 23.9 1.0 N C:LEU759 4.9 26.1 1.0 OG C:SER754 5.0 24.4 1.0

Chlorine binding site 3 out of 4 in the Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1302 b:63.1 occ:1.00 CL D:CYZ1302 0.0 63.1 1.0 C13 D:CYZ1302 1.8 39.8 1.0 C12 D:CYZ1302 2.8 38.5 1.0 C14 D:CYZ1302 2.8 34.8 1.0 O4 D:CYZ1302 2.9 39.0 1.0 S2 D:CYZ1302 3.2 42.2 1.0 N D:ASP760 3.2 45.8 1.0 O D:HOH1402 3.3 22.6 1.0 CA D:ASP760 3.5 48.4 1.0 CB D:ASP760 3.5 47.6 1.0 CB D:LEU759 3.6 36.5 1.0 N3 D:CYZ1302 3.6 35.0 1.0 C D:LEU759 3.7 39.9 1.0 C11 D:CYZ1302 4.0 34.1 1.0 OG A:SER729 4.1 34.3 1.0 C10 D:CYZ1302 4.1 32.8 1.0 CA D:LEU759 4.3 35.1 1.0 O D:LEU759 4.3 45.1 1.0 CG D:ASP760 4.5 54.1 1.0 C9 D:CYZ1302 4.6 28.6 1.0 O D:PHE495 4.6 35.0 1.0 CD1 D:LEU759 4.8 35.0 1.0 O3 D:CYZ1302 4.8 29.0 1.0 CG D:LEU759 4.8 33.4 1.0 OD1 D:ASP760 4.9 54.1 1.0

Chlorine binding site 4 out of 4 in the Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of- Function Tarp GAMMA2, with 150MM CACL2, 330UM Ctz, and 100MM L- Glutamate (Open-CA150) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:65.2 occ:1.00 CL A:CYZ1302 0.0 65.2 1.0 C13 A:CYZ1302 1.8 31.1 1.0 C12 A:CYZ1302 2.8 27.0 1.0 C14 A:CYZ1302 2.8 21.6 1.0 O4 A:CYZ1302 3.0 26.6 1.0 S2 A:CYZ1302 3.2 43.4 1.0 N A:ASP760 3.2 21.6 1.0 N3 A:CYZ1302 3.5 31.4 1.0 CB A:LEU759 3.6 17.2 1.0 CA A:ASP760 3.6 28.8 1.0 C A:LEU759 3.7 26.6 1.0 O A:HOH1401 3.7 20.2 1.0 CB A:ASP760 3.7 32.9 1.0 C11 A:CYZ1302 4.0 25.4 1.0 C10 A:CYZ1302 4.1 21.0 1.0 OD1 A:ASP760 4.1 43.6 1.0 CA A:LEU759 4.2 17.6 1.0 O A:LEU759 4.2 41.0 1.0 CG A:ASP760 4.3 43.3 1.0 C9 A:CYZ1302 4.6 23.1 1.0 O3 A:CYZ1302 4.8 31.0 1.0 CG A:LEU759 4.8 20.7 1.0 O A:PHE495 4.9 25.2 1.0 CD1 A:LEU759 4.9 22.1 1.0 N A:LEU759 4.9 27.1 1.0 CB D:SER729 5.0 22.5 1.0

T.Nakagawa, X.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3