Chlorine in PDB 8fqa: Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)

The binding sites of Chlorine atom in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) (pdb code 8fqa). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110), PDB code: 8fqa:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1302 b:74.9 occ:1.00 CL A:CYZ1302 0.0 74.9 1.0 C13 A:CYZ1302 1.8 50.9 1.0 C12 A:CYZ1302 2.7 51.5 1.0 C14 A:CYZ1302 2.8 46.8 1.0 O4 A:CYZ1302 3.0 62.0 1.0 OD1 A:ASP760 3.1 53.5 1.0 S2 A:CYZ1302 3.2 71.9 1.0 CG A:ASP760 3.3 55.0 1.0 OD2 A:ASP760 3.4 57.3 1.0 N3 A:CYZ1302 3.4 53.6 1.0 N A:ASP760 3.7 28.6 1.0 CB A:LEU759 3.7 49.6 1.0 O A:HOH1401 3.8 0.0 1.0 CA A:ASP760 3.9 37.9 1.0 C A:LEU759 4.0 32.8 1.0 C11 A:CYZ1302 4.0 49.7 1.0 C10 A:CYZ1302 4.1 40.5 1.0 CB A:ASP760 4.2 42.6 1.0 O A:LEU759 4.4 44.2 1.0 CA A:LEU759 4.5 31.5 1.0 O A:PHE495 4.5 38.2 1.0 C9 A:CYZ1302 4.6 45.4 1.0 CD1 A:LEU759 4.7 24.5 1.0 O3 A:CYZ1302 4.8 49.6 1.0 CG A:LEU759 4.9 42.1 1.0

Chlorine binding site 2 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1302 b:86.0 occ:1.00 CL B:CYZ1302 0.0 86.0 1.0 C13 B:CYZ1302 1.8 69.8 1.0 C12 B:CYZ1302 2.7 66.2 1.0 C14 B:CYZ1302 2.8 71.7 1.0 O4 B:CYZ1302 3.0 74.5 1.0 S2 B:CYZ1302 3.2 81.2 1.0 N B:ASP760 3.4 80.6 1.0 OD2 B:ASP760 3.4 82.1 1.0 N3 B:CYZ1302 3.4 64.5 1.0 CB B:LEU759 3.5 72.0 1.0 CG B:ASP760 3.5 85.8 1.0 C B:LEU759 3.5 73.2 1.0 CA B:ASP760 3.7 80.9 1.0 OD1 B:ASP760 3.8 87.0 1.0 O B:LEU759 3.9 74.2 1.0 C11 B:CYZ1302 4.0 66.5 1.0 C10 B:CYZ1302 4.1 68.7 1.0 CB B:ASP760 4.1 84.0 1.0 CA B:LEU759 4.1 74.8 1.0 OG C:SER729 4.4 59.9 1.0 O B:PHE495 4.5 64.2 1.0 C9 B:CYZ1302 4.6 68.3 1.0 CG B:LEU759 4.7 70.9 1.0 CD1 B:LEU759 4.8 71.2 1.0 O3 B:CYZ1302 4.8 74.5 1.0

Chlorine binding site 3 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1302 b:84.1 occ:1.00 CL C:CYZ1302 0.0 84.1 1.0 C13 C:CYZ1302 1.8 53.8 1.0 C12 C:CYZ1302 2.7 51.4 1.0 C14 C:CYZ1302 2.8 49.7 1.0 O4 C:CYZ1302 3.0 58.6 1.0 OD2 C:ASP760 3.1 56.6 1.0 S2 C:CYZ1302 3.2 74.5 1.0 CG C:ASP760 3.2 55.9 1.0 OD1 C:ASP760 3.3 56.8 1.0 N3 C:CYZ1302 3.4 60.7 1.0 N C:ASP760 3.4 35.9 1.0 CB C:LEU759 3.6 46.2 1.0 O C:HOH1401 3.7 5.3 1.0 C C:LEU759 3.7 36.6 1.0 CA C:ASP760 3.7 43.1 1.0 C11 C:CYZ1302 4.0 51.5 1.0 CB C:ASP760 4.1 48.3 1.0 C10 C:CYZ1302 4.1 46.2 1.0 O C:LEU759 4.1 46.4 1.0 CA C:LEU759 4.3 35.4 1.0 O C:PHE495 4.4 39.5 1.0 C9 C:CYZ1302 4.6 50.7 1.0 CD1 C:LEU759 4.8 29.1 1.0 CG C:LEU759 4.8 43.0 1.0 O3 C:CYZ1302 4.8 52.1 1.0

Chlorine binding site 4 out of 4 in the Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Lbd Conformation 2 (LBDCONF2) of GLUA2 Flip Q Isoform of Ampa Receptor in Complex with Gain-of-Function Tarp GAMMA2, with 140MM Nmdg, 330UM Ctz, and 100MM L-Glutamate (Open-NA110) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1302 b:85.8 occ:1.00 CL D:CYZ1302 0.0 85.8 1.0 C13 D:CYZ1302 1.8 67.9 1.0 C12 D:CYZ1302 2.7 62.7 1.0 C14 D:CYZ1302 2.8 73.1 1.0 O4 D:CYZ1302 3.0 74.8 1.0 S2 D:CYZ1302 3.2 85.8 1.0 OD1 D:ASP760 3.2 82.7 1.0 N D:ASP760 3.4 78.2 1.0 N3 D:CYZ1302 3.4 67.5 1.0 CB D:LEU759 3.5 72.1 1.0 CG D:ASP760 3.5 82.6 1.0 C D:LEU759 3.5 72.1 1.0 CA D:ASP760 3.6 80.5 1.0 O D:LEU759 3.8 74.2 1.0 OD2 D:ASP760 3.9 81.2 1.0 C11 D:CYZ1302 4.0 65.8 1.0 C10 D:CYZ1302 4.1 70.3 1.0 CA D:LEU759 4.1 74.4 1.0 CB D:ASP760 4.1 82.8 1.0 OG A:SER729 4.2 54.9 1.0 C9 D:CYZ1302 4.6 69.2 1.0 O D:PHE495 4.7 71.0 1.0 CG D:LEU759 4.7 71.0 1.0 CD1 D:LEU759 4.8 68.0 1.0 O3 D:CYZ1302 4.8 80.4 1.0 C D:ASP760 5.0 83.0 1.0

T.Nakagawa, X.T.Wang, F.J.Miguez-Cabello, D.Bowie. The Open Gate of the Ampa Receptor Forms A CA2+ Binding Site Critical in Regulating Ion Transport Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-024-01228-3